M9940
Mercaptoethylguanidine hemisulfate salt
≥98%
别名:
MEG hemisulfate salt
方案
≥98%
表单
solid
运输
wet ice
储存温度
2-8°C
SMILES字符串
OS(O)(=O)=O.NC(=N)NCCS.NC(=N)NCCS
InChI
1S/2C3H9N3S.H2O4S/c2*4-3(5)6-1-2-7;1-5(2,3)4/h2*7H,1-2H2,(H4,4,5,6);(H2,1,2,3,4)
InChI key
XJKZAAUVINNNNC-UHFFFAOYSA-N
应用
Selective iNOS inhibitor and scavenger of peroxynitrite.
生化/生理作用
Demonstrates potent antiinflammatory effects in an animal model of airway infection that mimics human cystic fibrosis.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Farzaneh Daghigh et al.
Journal of periodontology, 73(4), 392-400 (2002-05-07)
Although nitric oxide (NO) synthesis is increased in periodontal disease (PD), little is known about the possible sources of production by gingival tissues. In fact, gingival tissues from patients with periodontitis demonstrate greater levels of inducible nitric oxide (iNOS) expression
N Bank et al.
Kidney international, 58(1), 82-89 (2000-07-08)
In previous studies of transgenic sickle cell mice, increased renal expression of inducible nitric oxide synthase (iNOS) and endothelial cell isoform of NOS (EcNOS) was found by Western blot and immunohistochemistry. In addition, putative evidence of peroxynitrite (ONOO-) formation was
A Szabó et al.
Critical care medicine, 27(7), 1343-1350 (1999-08-14)
In rodent models, enhanced formation of nitric oxide and formation of peroxynitrite have been implicated in the pathogenesis of various forms of shock. Here we examined the effect of mercaptoethylguanidine (MEG), an inducible nitric oxide synthase inhibitor and peroxynitrite scavenger
Wiaam Badn et al.
Journal of immunology (Baltimore, Md. : 1950), 179(6), 4231-4238 (2007-09-06)
High-grade gliomas are one of the most aggressive human tumors with <1% of patients surviving 5 years after surgery. Immunotherapy could offer a possibility to eradicate remnant tumor cells after conventional therapy. Experimental immunotherapy can induce partial cure of established
M Whiteman et al.
British journal of pharmacology, 126(7), 1646-1652 (1999-05-14)
1. Peroxynitrite is a cytotoxic species that can be formed, among other mechanisms, by the rapid reaction of superoxide with nitric oxide. Peroxynitrite formation has been implicated in a wide range of neurodegenerative and chronic inflammatory diseases, as has the
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