M9940
Mercaptoethylguanidine hemisulfate salt
≥98%
别名:
MEG hemisulfate salt
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关于此项目
线性分子式:
H2NC(=NH)NHSCH2CH3 · 1/2 H2SO4
化学文摘社编号:
分子量:
168.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/2C3H9N3S.H2O4S/c2*4-3(5)6-1-2-7;1-5(2,3)4/h2*7H,1-2H2,(H4,4,5,6);(H2,1,2,3,4)
SMILES string
OS(O)(=O)=O.NC(=N)NCCS.NC(=N)NCCS
InChI key
XJKZAAUVINNNNC-UHFFFAOYSA-N
assay
≥98%
form
solid
shipped in
wet ice
storage temp.
2-8°C
Application
Selective iNOS inhibitor and scavenger of peroxynitrite.
Biochem/physiol Actions
Demonstrates potent antiinflammatory effects in an animal model of airway infection that mimics human cystic fibrosis.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Kiroycheva et al.
Journal of the American Society of Nephrology : JASN, 11(6), 1026-1032 (2000-05-23)
Previous studies in beta(s) sickle cell mice demonstrated renal immunostaining for nitrotyrosine, which is putative evidence of peroxynitrite (ONOO(-)) formation. ONOO(-) is known to nitrate tyrosine residues of various enzymes, thereby interfering with phosphorylation and inactivating them. The present study
The effect of inducible nitric oxide synthase (iNOS) inhibition on smoke inhalation injury in sheep.
K Soejima et al.
Shock (Augusta, Ga.), 13(4), 261-266 (2000-04-25)
Recent studies on smoke inhalation injury have been focused on nitric oxide (NO) as an essential factor of progressive lung injury. We studied the effects of inducible nitric oxide synthase (iNOS) inhibition on inhalation injury in sheep. Sheep (n =
K Soejima et al.
American journal of respiratory and critical care medicine, 163(3 Pt 1), 745-752 (2001-03-20)
Patients with severe burn and/or smoke inhalation injury suffer both systemic and pulmonary vascular hyperpermeability. We hypothesized that nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) plays a role in the changes in microvascular permeability seen with this
B Zingarelli et al.
The Journal of pharmacology and experimental therapeutics, 287(3), 1048-1055 (1998-12-24)
The effect of mercaptoethylguanidine (MEG), a selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger, was evaluated in a rat model of colonic injury. A single intracolonic administration of trinitrobenzene sulfonic acid (TNBS, 20 mg/kg) dissolved in ethanol
Mustafa Ozturk et al.
Journal of pineal research, 50(1), 89-96 (2010-11-11)
Doxorubicin (DOX) and Trastuzumab (TRAST) are effective agents for the treatment of many neoplastic diseases. Cardiotoxicity is a major side effect of these drugs and limit their use. In this study, the possible protective effects of melatonin (MEL), mercaptoethylguanidine (MEG)
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