产品名称
辅酶A（CoA）检测试剂盒, sufficient for 100 colorimetric or fluorometric tests
usage
sufficient for 100 colorimetric or fluorometric tests
detection method
colorimetric
fluorometric
functional group
phospholipid
relevant disease(s)
endocrinological disorders, diabetes; cancer
shipped in
wet ice
storage temp.
−20°C
Application
辅酶 A（CoA）检测试剂盒已用于测量 CoA 水平。
适用于测量细胞和组织裂解液等各种生物样品中的辅酶 A（CoA）
Biochem/physiol Actions
辅酶 A 检测试剂盒是一种测量各种生物样品中的 CoA 水平的简单方便的检测方法。CoA 浓度通过酶法测定，其产生与 CoA 浓度成比例的比色（570nm）/荧光测定（λex = 535 nm/λem = 587 nm）产物。该试剂盒的典型检测灵敏度为 0.1-10nmol CoA。
Features and Benefits
兼容高通量处理系统。
General description
辅酶A（CoA）是由半胱氨酸、泛酸和 ATP（三磷酸腺苷）合成的必需代谢辅助因子。CoA 在许多代谢途径中起重要作用，包括三羧酸循环，以及脂肪酸的合成和氧化。CoA 的主要功能之一是酰基的携带和转移。酰化衍生物，例如乙酰-CoA，是许多代谢反应中的关键中间体，特别是脂肪酸和碳水化合物代谢。在饥饿期间以及癌症、糖尿病和酗酒等条件下，CoA 水平可能会发生变化。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1
存储类别
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
法规信息
常规特殊物品
此项目有
Acetyl-CoA and the regulation of metabolism: mechanisms and consequences.
Current Opinion in Cell Biology, 33, 125-131 (2015)
Brandon C Rosen et al.
Antimicrobial agents and chemotherapy, 61(2) (2016-11-18)
Pyrazinamide (PZA) is a first-line tuberculosis (TB) drug that has been in clinical use for 60 years yet still has an unresolved mechanism of action. Based upon the observation that the minimum concentration of PZA required to inhibit the growth
Long-Chain Fatty Acyl-CoA Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.
Rosen B C, et al.
Antimicrobial Agents and Chemotherapy, AAC-02130 (2016)
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Science, 291(5513), 2613-2616 (2001)
The subcellular localization of acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Proceedings of the National Academy of Sciences of the USA, 97(4), 1444-1449 (2000)
商品
Sigma article discusses tumor cell metabolic pathways, focusing on aerobic glycolysis and mitochondrial activity.
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
本文介绍了增殖活性细胞为何需要碳源和氮源合成大分子。尽管大部分肿瘤细胞利用有氧糖酵解途径并分流线粒体氧化磷酸化代谢物，但许多肿瘤细胞表现出线粒体活性增加。
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持