用途
sufficient for 100 colorimetric tests
检测方法
colorimetric
相关疾病
cardiovascular diseases; cancer; hematological disorder
储存温度
−20°C
一般描述
醛脱氢酶（ALDH）是一类催化外源性醛和内源性醛的代谢、防止潜在反应性醛和毒性醛及其代谢物的积累的酶。除了它们在醛代谢中的作用外，ALDH酶还在其他细胞过程中起关键作用，例如细胞增殖，分化和存活。ALDH家族成员的突变与许多疾病有关，如心脏病、白内障和某些癌症。ALDH活性也可以作为某些干细胞群（包括造血干细胞和某些癌症干细胞）的标志物。
应用
适用于对包括组织和细胞在内的多种样品中的醛脱氢酶（ALDH）进行测定
醛脱氢酶活性比色检测试剂盒用于检测醛脱氢酶的活性。
生化/生理作用
醛脱氢酶活性比色检测试剂盒提供了一种可简单直接地检测各种样品中NAD依赖性ALDH活性的方法。ALDH活性通过酶偶联法检测，其中乙醛被ALDH氧化生成NADH，NADH与探针反应，产生比色(450 nm)产物，该产物与存在的ALDH活性成比例。一单位ALDH是指该酶在室温、pH 8.0条件下每分钟产生1.0 μmM NADH的量。
特点和优势
与高通量处理系统相容。
警示用语：
Danger
危险声明
危险分类
Carc. 1B - Eye Dam. 1 - Skin Corr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
法规信息
含少量动物源组分生物产品
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The effects of antiviral treatment on breast cancer cell line.
Shaimerdenova M, et al.
Infectious Agents and Cancer, 12(1), 18-18 (2017)
Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application.
Vindhya K, et al.
Pharmacological Reviews, 64(3), 520-539 (2012)
Xiaoman Li et al.
Experimental hematology & oncology, 11(1), 2-2 (2022-01-22)
Tanshinone II A is an effective component extracted from Salvia miltiorrhiza and the roles of Tanshinone IIA in regulating the stemness of tumor cells remain unclear. This work aims to explore the roles and underlying mechanisms of Tanshinone IIA in
Xiaotian Xu et al.
Aging, 14(11), 4858-4873 (2022-06-10)
The roles of asparagine-linked glycosylation (ALG) members in tumorigenic process have been widely explored. However, their effects in colorectal cancer progression are still confusing. Here, we screened 12 ALGs' expression through online datasets and found that ALG10 was mostly upregulated
Ting Liu et al.
Bioengineered, 12(1), 7143-7155 (2021-09-22)
Cancer stem cell (CSC) has been confirmed to trigger tumor occurrence and progression and CSC can develop strategies to maintain a lower reactive oxygen species (ROS) level compared to cancer cells. However, the mechanisms contributing to ROS homeostasis in CSC
商品
AldeRed™ 588-A detects ALDH activity in cancer stem cells, aiding in cancer research.
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