detection method
fluorometric
relevant disease(s)
endocrinological disorders, diabetes; cardiovascular diseases; cancer
storage temp.
−20°C
Gene Information
human ... CTSS(1520)
mouse ... CTSS(13040)
rat ... CTSS(50654)
General description
Cathepsin S (CTSS; EC 3.4.22.27) is a lysosomal cysteine proteinase involved in the degradation of proteins to peptides required for the presentation of MHC class II molecules.1 It is associated with pathological conditions such as atherosclerosis, coronary heart disease, cancer, and insulin resistance.
Application
适于筛选组织蛋白酶S的抑制剂。
Biochem/physiol Actions
The Cathepsin S Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSS. CTSS activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/ λem = 505 nm), proportional to the enzymatic activity present.
仅试剂盒组分
产品编号
说明
- CTSS Reaction Buffer
- Cathepsin S, human
- CTSS Substrate, Z-VVR-AFC, 10 mM
- CTSS Inhibitor Z-FF-FMK, 1 mM
存储类别
10 - Combustible liquids
法规信息
常规特殊物品
此项目有
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持