检测方法
fluorometric
相关疾病
hematological disorder
储存温度
−20°C
一般描述
The coagulation Factor IX (or Christmas factor) (EC 3.4.21.22) is a vitamin K-dependent serine protease. Factor IX is produced as an inactive precursor and is activated via cleavage by either factor XIa (contact pathway) or factor VIIa (tissue factor pathway). In the presence of calcium ions and negatively charged membrane phospholipids, activated factor IX (FIXa) then binds to the activated Factor VIII (FVIIIa) and proteolytically activates factor X (FX) to factor Xa (FXa). Deficiency in factor IX causes hemophilia B, an X-linked bleeding disorder.
应用
Suitable to determine the activity of purified Factor IX and to detect the activity of Factor IX in plasma and serum.
生化/生理作用
This Factor IXa Activity Assay kit is based on the ability of FIXa to generate FXa. The generated FXa proteolytically cleaves a synthetic substrate and releases a fluorophore, AMC, which can be easily quantified by fluorescence microplate reader. The assay is simple, rapid, and can detect activity as low as 10 pg of FIXa in a variety of samples.
储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Adenovirus-associated virus vector--mediated gene transfer in hemophilia B
Nathwani A C. et al.
The New England Journal of Medicine, 365(25), 2357-2365 (2011)
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