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关于此项目
经验公式(希尔记法):
C22H16N2O6
化学文摘社编号:
分子量:
404.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI key
UUDYZUDTQPLDDP-UHFFFAOYSA-N
SMILES string
OC(=O)c1cc(C(O)=O)c(NC(=O)c2ccccc2)cc1NC(=O)c3ccccc3
InChI
1S/C22H16N2O6/c25-19(13-7-3-1-4-8-13)23-17-12-18(16(22(29)30)11-15(17)21(27)28)24-20(26)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: ~24 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
First non-competitive antagonist of GluK5 receptor.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
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Saravanapriah Nadarajan et al.
Development (Cambridge, England), 136(13), 2223-2234 (2009-06-09)
Fertility depends on germline stem cell proliferation, meiosis and gametogenesis, yet how these key transitions are coordinated is unclear. In C. elegans, we show that GLP-1/Notch signaling functions in the germline to modulate oocyte growth when sperm are available for
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Journal of cell science, 124(Pt 9), 1510-1518 (2011-04-20)
Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells that, depending on the cellular milieu, can either promote survival or act as an alternative mechanism of programmed cell death (PCD) in terminally differentiated cells. Despite the important developmental and medical
Peter E A Ash et al.
Human molecular genetics, 19(16), 3206-3218 (2010-06-10)
RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenient in vivo model
Katherine R Schouest et al.
PloS one, 4(10), e7450-e7450 (2009-10-15)
The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses. Although diverse, these functions have been
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