N165
Naloxone benzoylhydrazone
solid
别名:
[(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazide benzoic acid
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关于此项目
经验公式（希尔记法）:
C26H27N3O4
化学文摘社编号:
分子量:
445.51
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
质量水平
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
yellow
溶解性
DMSO: soluble
H2O: soluble (with the addition of 0.1 N HCl)
ethanol: soluble
储存温度
−20°C
SMILES字符串
[H][C@@]12Oc3c(O)ccc4C[C@H]5N(CC[C@@]1(c34)[C@@]5(O)CC\C2=N/NC(=O)c6ccccc6)CC=C
InChI
1S/C26H27N3O4/c1-2-13-29-14-12-25-21-17-8-9-19(30)22(21)33-23(25)18(10-11-26(25,32)20(29)15-17)27-28-24(31)16-6-4-3-5-7-16/h2-9,20,23,30,32H,1,10-15H2,(H,28,31)/b27-18+/t20-,23+,25+,26-/m1/s1
InChI key
AKXCFAYOTIEFOH-XTNAHFASSA-N
基因信息
human ... OPRK1(4986), OPRL1(4987), OPRM1(4988)
生化/生理作用
Agonist for κ3 opioid receptors; antagonist for ORL1 and μ opioid receptors.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Mark Connor et al.
British journal of pharmacology, 147(4), 349-350 (2006-01-13)
Mu-opioid receptor agonists are a mainstay of clinical analgesia, despite the significant unwanted effects and dependence liability associated with drugs like morphine. The quest for opioids that produce analgesia with fewer undesirable effects has lead to the putative identification of
S Liu et al.
American journal of physiology. Gastrointestinal and liver physiology, 281(1), G237-G246 (2001-06-16)
Actions of nociceptin on electrical and synaptic behavior of morphologically and neurochemically identified neurons in the guinea pig duodenal myenteric plexus were studied with conventional techniques. Nociceptin hyperpolarized the membrane potential in 104 of 121 AH-type and 28 of 51
M A Gistrak et al.
The Journal of pharmacology and experimental therapeutics, 251(2), 469-476 (1989-11-01)
NalBzoH (6-desoxy-6-benzoylhydrazido-N-allyl-14-hydroxydihydronomorphin one) is a novel opiate with potent actions at both mu and kappa receptors. Analgesic studies in mice examining increasing doses of NalBzoH with a fixed dose of morphine revealed a biphasic curve. NalBzoH at doses as low
R Bigoni et al.
Canadian journal of physiology and pharmacology, 80(5), 407-412 (2002-06-12)
We have studied the effects of naloxone benzoylhydrazone (NalBzoH) at recombinant human OP4 receptors expressed in Chinese hamster ovary (CHO) cells (CHOhOP4) and native OP4 sites in isolated tissues from various species. In CHOhOP4 membranes, nociceptin (NC) and NalBzoH displaced
J P Mathis et al.
Synapse (New York, N.Y.), 34(3), 181-186 (1999-10-19)
The presence of pairs of basic amino acids within the orphanin FQ/Nociceptin (OFQ/N) sequence has raised the possibility that truncated versions of the peptide might be physiologically important. OFQ/N(1-11) is pharmacologically active in mice, despite its poor affinity in binding
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