N211
NS 2028
solid
别名:
4H-8-Bromo-1,2,4-oxadiazolo[3,4-d]benz[b][1,4]oxazin-1-one
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关于此项目
经验公式（希尔记法）:
C9H5BrN2O3
化学文摘社编号:
分子量:
269.05
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
InChI key
MUDRLQRJCGJJTB-UHFFFAOYSA-N
SMILES string
Brc1ccc2OCC3=NOC(=O)N3c2c1
InChI
1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
form
solid
color
white
solubility
DMSO: 13 mg/mL, ethanol: 4.8 mg/mL, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble
Gene Information
human ... GUCY1A2(2977), GUCY1A3(2982), GUCY1B2(2974), GUCY1B3(2983)
Biochem/physiol Actions
Specific, soluble guanylyl cyclase inhibitor.
Legal Information
Sold under exclusive license from NeuroSearch A/S.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
S P Olesen et al.
British journal of pharmacology, 123(2), 299-309 (1998-03-07)
1 The haeme-containing soluble guanylyl cyclase (alpha1beta1-heterodimer) is a major intracellular receptor and effector for nitric oxide (NO) and carbon monoxide (CO) and mediates many of their biological actions by increasing cyclic GMP. We have synthesized new oxadiazolo-benz-oxazins and have
Patricia Pablos et al.
Neuropharmacology, 99, 422-431 (2015-08-10)
Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat locus coeruleus (LC). Perfusion with ME (3 and 10 μM) concentration-dependently reduced subsequent
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