N219
诺考达唑
solid
别名:
诺考达唑, R 17934, 甲基-(5-噻吩甲酰-2-苯并咪唑基)氨基甲酸, 甲基N(5-噻吩甲酰-2-苯并咪唑基)氨基甲酸
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关于此项目
经验公式（希尔记法）:
C14H11N3O3S
化学文摘社编号:
分子量:
301.32
EC Number:
250-626-5
UNSPSC Code:
41116107
MDL number:
Beilstein/REAXYS Number:
1085978
InChI
1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChI key
KYRVNWMVYQXFEU-UHFFFAOYSA-N
SMILES string
COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3cccs3
form
solid
color
white
mp
300 °C (dec.)
solubility
DMSO: 4 mg/mL, H2O: insoluble
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Biochem/physiol Actions
Promotes tubulin depolymerization; inhibits mitosis.
signalword
Warning
hcodes
Hazard Classifications
Muta. 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Kuhn
FEMS microbiology letters, 160(1), 87-90 (1998-03-12)
Uptake of Listeria monocytogenes by different mammalian cells like macrophages and epithelial cells is dependent on functional actin filaments and hence susceptible to inhibition by cytochalasin. Here we show that phagocytic uptake of L. monocytogenes by P388D1 macrophages is also
R S Haltiwanger et al.
The Journal of biological chemistry, 272(13), 8752-8758 (1997-03-28)
O-Linked N-acetylglucosamine (O-GlcNAc) is a ubiquitous and abundant protein modification found on nuclear and cytoplasmic proteins. Several lines of evidence suggest that it is a highly dynamic modification and that the levels of this sugar on proteins may be regulated.
R D Huby et al.
The Journal of biological chemistry, 273(20), 12024-12031 (1998-06-20)
The potential role of the cytoskeleton in signaling via the T cell antigen receptor (TCR) was investigated using pharmacological agents. In Jurkat T cells, disruption of the actin-based cytoskeleton with cytochalasin D or disruption of the microtubules with colchicine did
William G Waples et al.
Molecular biology of the cell, 20(1), 245-255 (2008-10-17)
The completion of chromosome segregation during anaphase requires the hypercondensation of the approximately 1-Mb rDNA array, a reaction dependent on condensin and Cdc14 phosphatase. Using systematic genetic screens, we identified 29 novel genetic interactions with budding yeast condensin. Of these
Alan Michael Tartakoff et al.
Molecular biology of the cell, 20(12), 2932-2942 (2009-04-17)
When haploid cells of Saccharomyces cerevisiae are crossed, parental nuclei congress and fuse with each other. To investigate underlying mechanisms, we have developed assays that evaluate the impact of drugs and mutations. Nuclear congression is inhibited by drugs that perturb
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