N2643
Anti-Nitric Oxide Synthase, Endothelial (596-609) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-eNOS
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IHC (f), WB
Citations:
8
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, bovine
technique(s)
immunohistochemistry (frozen sections): 1:100 using acetone-fixed, frozen tissue sections of mouse heart, microarray: suitable, western blot: 1:10,000 using bovine lung endothelial cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NOS3(4846)
mouse ... Nos3(18127)
General description
The gene encoding endothelial nitric oxide synthase (eNOS) is localized on human chromosome 7q35-36 and has 26 exons.
eNOS encodes a 135 kDa protein and is localized in endothelial cells. Human bNOS and eNOS share 52% amino acid identity, and rat and human bNOS share 93% amino acid identity. eNOS is not restricted to the endothelium of blood vessels but exists in the epithelium of several tissues.
Immunogen
synthetic peptide corresponding to nitric oxide synthase (NOS) of bovine endothelial origin (eNOS, amino acids 596-609) conjugated to KLH. The immunogen sequence is identical in human eNOS.
Application
Anti-Nitric Oxide Synthase, Endothelial (596-609) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Endothelial nitric oxide synthase (eNOS) is a modulator of vascular function and it is involved in the production of nitric oxide. Defects in the enzyme expression have been shown to be associated coronary artery disease.
Endothelial nitric oxide synthase (eNOS) is constitutively expressed and are dependent on Ca2+/ calmodulin for nitricoxide (NO) production.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Ang-(1-7) protects HUVECs from high glucose-induced injury and inflammation via inhibition of the JAK2/STAT3 pathway
Chen J, et al.
International Journal of Molecular Medicine, 41(5), 2865-2878 (2018)
Vascular nitric oxide: Beyond eNOS
Zhao Y, et al.
Journal of Pharmacological Sciences, 129(2), 83-94 (2015)
Nitric oxide production by mouse renal tubules can be increased by a sodium-dependent mechanism
Kempson S, et al.
Nitric Oxide, 17(1), 33-43 (2007)
Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298
Tesauro M, et al.
Proceedings of the National Academy of Sciences of the USA, 97(6), 2832-2835 (2000)
Molecular basis of cell-specific endothelial nitric-oxide synthase expression in airway epithelium
German Z, et al.
The Journal of Biological Chemistry, 275(11), 8183-8189 (2000)
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