N2915
PYR-41
≥98% (HPLC), powder
别名:
4-[4-[(5-硝基-2-呋喃基)亚甲基]-3,5-二氧代-1-吡唑烷基]苯甲酸乙酯
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
red to brown
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
−20°C
SMILES字符串
CCOC(=O)c1ccc(cc1)N2NC(=O)\C(=C/c3ccc(o3)[N+]([O-])=O)C2=O
InChI
1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9+
InChI key
ARGIPZKQJGFSGQ-UKTHLTGXSA-N
相关类别
应用
PYR-41已被用作E1抑制剂：
- 用于确定腺相关病毒（AAV）转导的细胞降解途径
- 通过基质辅助激光解吸/电离飞行时间（MALDI-TOF）E2/E3分析，评估其选择性和效力
- 处理高葡萄糖培养基中完全分化的C2C12肌管，以确定其对蛋白质泛素化和细胞活力的影响
- 预处理人脑微血管内皮细胞（hBMEC），用于细菌感染前的抑制研究
生化/生理作用
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂.
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂，对E3、E2或半胱天冬酶的活性几乎无活性或完全无活性。
PYR-41能够抑制E1泛素连接酶，如小鼠双微基因2同源物（MDM2）、痒同源物（ITCH）和HOIL-1L相互作用蛋白（HOIP）的E1泛素连接酶。 它具有潜在的抗癌作用。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Chun-Tao Lei et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 42(1), 281-294 (2017-05-24)
Protein Kinase C-α (PKC-α) and epidermal growth factor receptor (EGFR) are both involved in diabetic kidney disease; however, the connection between these two proteins during high glucose-induced podocyte injury remains uncertain. Diabetes was induced in SD rats by streptozotocin (STZ).
Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats
Reddy SS, et al.
Archives of Biochemistry and Biophysics, 639(9), 16-25 (2018)
Tyler G Franklin et al.
Frontiers in chemistry, 7, 816-816 (2019-12-24)
Protein ubiquitination is a highly orchestrated process that controls diverse aspects of human biology. Dysregulation of this process can lead to various disease states including cancer, neurodegeneration, and autoimmunity. It is the correction of these dysregulated pathways, as well as
Inês B Santarino et al.
Scientific reports, 7(1), 5812-5812 (2017-07-21)
Erythrophagocytosis, the phagocytic removal of damaged red blood cells (RBC), and subsequent phagolysosome biogenesis are important processes in iron/heme metabolism and homeostasis. Phagolysosome biogenesis implies the interaction of nascent phagosomes with endocytic compartments and also autophagy effectors. Here, we report
Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking
Surve MV, et al.
PLoS Pathogens, 14(7), e1007168-e1007168 (2018)
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