N2915
PYR-41
≥98% (HPLC), powder
别名:
4-[4-[(5-硝基-2-呋喃基)亚甲基]-3,5-二氧代-1-吡唑烷基]苯甲酸乙酯
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选择尺寸
关于此项目
经验公式（希尔记法）:
C17H13N3O7
化学文摘社编号:
分子量:
371.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
PYR-41, ≥98% (HPLC), powder
SMILES string
CCOC(=O)c1ccc(cc1)N2NC(=O)\C(=C/c3ccc(o3)[N+]([O-])=O)C2=O
InChI
1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9+
InChI key
ARGIPZKQJGFSGQ-UKTHLTGXSA-N
assay
≥98% (HPLC)
form
powder
color
red to brown
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
相关类别
Application
PYR-41已被用作E1抑制剂：
- 用于确定腺相关病毒（AAV）转导的细胞降解途径
- 通过基质辅助激光解吸/电离飞行时间（MALDI-TOF）E2/E3分析，评估其选择性和效力
- 处理高葡萄糖培养基中完全分化的C2C12肌管，以确定其对蛋白质泛素化和细胞活力的影响
- 预处理人脑微血管内皮细胞（hBMEC），用于细菌感染前的抑制研究
Biochem/physiol Actions
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂.
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂，对E3、E2或半胱天冬酶的活性几乎无活性或完全无活性。
PYR-41能够抑制E1泛素连接酶，如小鼠双微基因2同源物（MDM2）、痒同源物（ITCH）和HOIL-1L相互作用蛋白（HOIP）的E1泛素连接酶。 它具有潜在的抗癌作用。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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