N3258
烟酰胺N-氧化物
≥98%
别名:
3-Pyridinecarboxamide, Oxynicotinamide
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关于此项目
经验公式（希尔记法）:
C6H6N2O2
化学文摘社编号:
分子量:
138.12
UNSPSC Code:
41106305
PubChem Substance ID:
EC Number:
217-859-4
MDL number:
InChI key
USSFUVKEHXDAPM-UHFFFAOYSA-N
InChI
1S/C6H6N2O2/c7-6(9)5-2-1-3-8(10)4-5/h1-4H,(H2,7,9)
SMILES string
NC(=O)c1ccc[n+]([O-])c1
assay
≥98%
mp
291-293 °C (dec.) (lit.)
Biochem/physiol Actions
Nicotinamide N-oxide is a niacin-related compound used in studies of mechanisms of niacin-related granulocyte differentiation of cells such as human promyelocytic leukemia cells (HL-60). Nicotinamide N-oxide reduced expression of c-myc in HL-60 cell line.
hcodes
signalword
Warning
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
K Takekawa et al.
Xenobiotica; the fate of foreign compounds in biological systems, 31(1), 11-23 (2001-05-04)
1. The mechanism of reduction of aliphatic tertiary amine N-oxides to tertiary amines in liver microsomes was examined and a novel type of reduction by cytochrome P450 was found. 2. Rat liver microsomes exhibited a significant N-oxide reductase activity toward
S Shimada et al.
Investigative ophthalmology & visual science, 28(7), 1204-1206 (1987-07-01)
The nicotinamide N-oxide reductase activity of a variety of ocular tissues was investigated. The 9,000g supernatant of ciliary body, retinal pigment epithelium-choroid, iris, retina and cornea, but not lens, exhibited reductase activity under anaerobic conditions when supplemented with 2-hydroxypyrimidine, an
Spectroscopic (NMR, UV, FT-IR and FT-Raman) analysis and theoretical investigation of nicotinamide N-oxide with density functional theory.
Atac A, Karabacak M, Kose E, Karaca C.
Spectrochimica Acta Part A: Molecular Spectroscopy, 83(1), 250-258 (2011)
R M Menon et al.
International journal of clinical pharmacology and therapeutics, 45(8), 448-454 (2007-08-30)
To characterize plasma and urine pharmacokinetics of niacin and its metabolites after oral administration of 2,000 mg of extended-release (ER) niacin in healthy male volunteers. Niacin ER was administered to 12 healthy male subjects following a low-fat snack. Plasma was
Mark W Ruddock et al.
Oncology research, 16(12), 569-574 (2008-03-21)
Nicotinamide is a potent radiosensitizer currently employed in the treatment of cancer of the bladder, head, and neck. Unfortunately, nicotinamide is also a potent emetic at the concentrations required for radiosensitization. Previously, we have demonstrated that nicotinamide-induced emesis is the
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