N3529
NAN-190 hydrobromide
别名:
1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide
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关于此项目
经验公式（希尔记法）:
C23H27N3O3 · HBr
化学文摘社编号:
分子量:
474.39
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C23H27N3O3.BrH/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28;/h2-5,8-11H,6-7,12-17H2,1H3;1H
SMILES string
Br.COc1ccccc1N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2
InChI key
AXRUEPFPTQYHQD-UHFFFAOYSA-N
Gene Information
human ... HTR1A(3350)
Biochem/physiol Actions
Potent 5-HT1A serotonin receptor antagonist active in the nM range.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
J E Duffy-Whritenour et al.
Brain, behavior, and immunity, 22(2), 257-264 (2007-09-26)
An immunomodulatory role for serotonin (5-HT) has been demonstrated in mammals and evidence for a similar role for 5-HT has recently emerged in fish. However, as limited studies are available, discrepancies often exist regarding the role of 5-HT in the
R L Dennis et al.
Poultry science, 87(4), 612-620 (2008-03-15)
Serotonin (5-HT) regulates aggressive behavior via binding to its receptors, such as 5-HT1A and 1B, in humans and rodents. Here we investigate the heritable components of 5-HT regulation of aggressiveness in chickens, utilizing 3 distinct genetic strains. In this study
L Rydelek-Fitzgerald et al.
Brain research, 532(1-2), 191-196 (1990-11-05)
NAN-190 has been reported to be a 5-HT1A antagonist in drug discrimination studies. In order to determine if the effect of NAN-190 was directly due to competitive inhibition at 5-HT1A receptors, 5-HT1A-mediated inhibition of adenylyl cyclase in hippocampal membranes was
James Oluwagbamigbe Fajemiroye et al.
Journal of ethnopharmacology, 141(3), 872-877 (2012-04-05)
Medicinal applications of Pimenta pseudocaryophyllus infusion as a diuretic and aphrodisiac agent as well as tranquilizer in the form of tea for the treatment of emotional tension in Brazilian folk medicine has been in practice since time immemorial. Despite its
Jaime Pei Pei Foong et al.
Neuroreport, 20(3), 325-330 (2009-02-05)
Serotonin (5-HT) plays a significant role in the regulation of intestinal secretion of water and electrolytes. The initial aim of this study was to use intracellular recording and specific antagonists to identify roles of 5-HT1A and 5-HT7 receptors of submucosal
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