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Merck
CN

N4396

Nalbuphine hydrochloride hydrate

≥98% (HPLC), powder, μ and κ opioid receptors agonist

别名:

17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride hydrate

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关于此项目

经验公式（希尔记法）:
C21H27NO4 · HCl · xH2O
化学文摘社编号:
23277-43-2
分子量:
393.90 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24278052
NACRES:
NA.77
EC Number:
245-549-9

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产品名称

Nalbuphine hydrochloride hydrate, ≥98% (HPLC)

InChI

1S/C21H27NO4.ClH.H2O/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12;;/h4-5,12,15-16,19,23-25H,1-3,6-11H2;1H;1H2/t15-,16+,19-,20-,21+;;/m0../s1

InChI key

IUGXDRGXUYNFHK-XSFMULHUSA-N

SMILES string

Cl[H].[H]O[H].[H][C@@]12Oc3c(O)ccc4C[C@H]5N(CC[C@@]1(c34)[C@@]5(O)CC[C@@H]2O)CC6CCC6

assay

≥98% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: soluble, ethanol: soluble

originator

Abbott

Quality Level

100

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)

相关类别

General description

Nalbuphine functions as an analgesic. It has anti catabolic properties. Nalbuphine maybe associated with sedation, nausea and vomiting.

Biochem/physiol Actions

Partial agonist for μ and κ opioid receptors.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCS4727
MKCN7821
MKCK6841
MKCG5989
MKCF1637

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P J Emmerson et al.
Journal of neurochemistry, 73(1), 289-300 (1999-07-01)
The influence of membrane microviscosity on mu-opioid agonist and antagonist binding, as well as agonist efficacy, was examined in membranes prepared from SH-SY5Y cells and from a C6 glioma cell line stably expressing the rat mu-opioid receptor (C6mu). Addition of
Three cases of nalbuphine hydrochloride dependence associated with anabolic steroid use.
McBride AJ, et al.
British Journal of Sports Medicine, 30(1), 69-70 (1996)
Evaluation of nalbuphine hydrochloride
Miller RR
American Journal of Health-System Pharmacy, 37(7), 942-949 (1980)
L R Gerak et al.
The Journal of pharmacology and experimental therapeutics, 276(2), 523-531 (1996-02-01)
Three rhesus monkeys discriminated between 0.178 mg/kg of nalbuphine and saline while responding under a fixed-ratio 5 schedule of stimulus-shock termination. Nalbuphine produced dose-related increases in drug-lever responding with > or = 90% of responses occurring on the drug lever
Nalbuphine
Schmidt WK, et al.
Drug and Alcohol Dependence, 14(3-4), 339-362 (1985)
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