InChI key
UZMVSVHUTOAPTD-UHFFFAOYSA-N
InChI
1S/C6H12N2O/c9-7-8-5-3-1-2-4-6-8/h1-6H2
SMILES string
O=NN1CCCCCC1
form
liquid
refractive index
n20/D 1.497 (lit.)
bp
233 °C (lit.)
density
1.06 g/mL at 25 °C (lit.)
storage temp.
2-8°C
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Biochem/physiol Actions
Mutagenic and carcinogenic. A trace-enrichment HPLC method has been developed for quantitating this compound as an impurity (to ppb levels) in tolazamide, and potentially other pharmaceutical preparations.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
210.2 °F - closed cup
flash_point_c
99 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
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A E Ross et al.
Cancer letters, 15(3), 329-334 (1982-03-01)
Liver DNA and RNA were isolated from rats treated with the liver carcinogens N-nitrosopyrrolidine (NPYR) and N-nitrosohexamethyleneimine (NHX). After hydrolysis in 70% perchloric acid (100 degrees C, 1.0 h), 70% of the radioactivity in both the DNA and RNA hydrolysates
L I Hecker et al.
Cancer research, 42(1), 59-64 (1982-01-01)
The in vitro metabolism of N-nitrosohexamethyleneimine by lung and liver microsomes and cytosol from uninduced male Fischer rats is described. Metabolites produced by both organs appeared to be identical. The liver subcellular fractions had a lower Km (0.6 mM) than
L I Hecker et al.
Carcinogenesis, 1(12), 1017-1025 (1980-01-01)
Stable hydroxylated metabolites of N-nitrosohexamethyleneimine (NO-HEX) account for about one-third of the metabolites produced in in vitro reactions using uninduced rat liver microsomes post-microsomal supernatant. The ratio of gamma- to beta-hydroxyNO-HEX thus produced is 3:1. Each of these isomers exists
G W Harrington et al.
Cancer letters, 32(2), 187-191 (1986-08-01)
Tolazamide, an antidiabetic drug, was found to produce N-nitrosohexamethyleneimine (NHM) upon exposure to an oxidizing agent and in the absence of a nitrosating agent. The oxidizing agents were either hydrogen peroxide or oxygen.
W Lijinsky et al.
Cancer letters, 12(1-2), 99-103 (1981-03-01)
Three homologous cyclic nitrosamines, nitrosopyrrolidine, nitrosopiperidine and nitrosohexamethyleneimine, were administered to groups of 20 female F344 rats in drinking water, as 0.9 mM solutions. Treatment with the latter 2 compounds lasted 28 weeks, at which time several animals had died
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