N5770
Nalmefene
别名:
(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
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关于此项目
经验公式（希尔记法）:
C21H25NO3
化学文摘社编号:
分子量:
339.43
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Form:
solid
form
solid
originator
Baxter
storage temp.
2-8°C
SMILES string
Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=C)CC[C@@]35O)CC6CC6
InChI
1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1
InChI key
WJBLNOPPDWQMCH-MBPVOVBZSA-N
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Oprd1(24613), Oprm1(25601)
Biochem/physiol Actions
Nonselective opioid receptor antagonist.
Features and Benefits
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Hong-liang Wang et al.
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 22(6), 351-353 (2010-07-03)
To study the effect of nalmefene in treatment of patients with septic shock. Twenty patients, suffering from septic shock, admitted to the intensive care unit (ICU) from December, 2008 to June, 2009, were randomly divided into treatment group and control
Jon E Grant et al.
Psychopharmacology, 200(4), 521-527 (2008-06-27)
Although opiate antagonists have shown promise in the treatment of pathological gambling (PG), individual responses vary. No studies have systematically examined predictors of medication treatment outcome in PG. Understanding clinical variables related to treatment outcome should help generate treatment algorithms
M E Michel et al.
Methods and findings in experimental and clinical pharmacology, 7(4), 175-177 (1985-04-01)
Nalmefene (6-methylene-naltrexone) is a potent, orally active, opiate antagonist. IC50's were obtained for nalmefene, naloxone and naltrexone using radiolabelled prototype ligands for mu, kappa and delta receptors in homogenates of rat brain minus cerebellum. Nalmefene antagonized the bindings of [3H]-dihydromorphine