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关于此项目
经验公式(希尔记法):
C21H25NO3
化学文摘社编号:
分子量:
339.43
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1
SMILES string
Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=C)CC[C@@]35O)CC6CC6
InChI key
WJBLNOPPDWQMCH-MBPVOVBZSA-N
form
solid
originator
Baxter
storage temp.
2-8°C
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Oprd1(24613), Oprm1(25601)
Biochem/physiol Actions
Nonselective opioid receptor antagonist.
Features and Benefits
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Hong-liang Wang et al.
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 22(6), 351-353 (2010-07-03)
To study the effect of nalmefene in treatment of patients with septic shock. Twenty patients, suffering from septic shock, admitted to the intensive care unit (ICU) from December, 2008 to June, 2009, were randomly divided into treatment group and control
Jon E Grant et al.
Psychopharmacology, 200(4), 521-527 (2008-06-27)
Although opiate antagonists have shown promise in the treatment of pathological gambling (PG), individual responses vary. No studies have systematically examined predictors of medication treatment outcome in PG. Understanding clinical variables related to treatment outcome should help generate treatment algorithms
Stephani A Day et al.
Biochemical pharmacology, 81(8), 996-1003 (2011-02-05)
Hepatic fibrosis is characterized by excess type I collagen deposition and exacerbated inflammatory response. Naltrexone, an opioid receptor antagonist used for treating alcohol abuse, attenuates hepatocellular injury in fibrotic animal models, which can be accompanied by deleterious side effects. Additionally
Ngoc Quan Phan et al.
Journal of the American Academy of Dermatology, 63(4), 680-688 (2010-05-14)
During the past two decades, systemic μ-opioid receptor antagonists (MORA) have been used in the treatment of various forms of chronic pruritus. In a number of case reports, case series, and controlled trials, treatment with MORA has demonstrated considerable antipruritic
Trial watch: Nalmefene reduces alcohol use in phase III trial.
Nature reviews. Drug discovery, 10(8), 566-566 (2011-08-02)
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