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Merck
CN

N7001

2-Nitro-4-carboxyphenyl N,N-diphenylcarbamate

别名:

NCDC

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关于此项目

经验公式（希尔记法）:
C20H14N2O6
化学文摘社编号:
10556-88-4
分子量:
378.33
UNSPSC Code:
12352202
MDL number:
MFCD00057605

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SMILES string

OC(=O)c1ccc(OC(=O)N(c2ccccc2)c3ccccc3)c(c1)N(=O)=O

Application

Can be used for the determination of chymotrypsin; liberates 4-hydroxy-3-nitrobenzoic acid (also available from Sigma).

Biochem/physiol Actions

Specific chromogenic inactivator of chymotrypsin. Inhibits anti-IgE-mediated histamine release and inositol trisphosphate (IP3) production in mast cells, possibly by a mechanism involving inhibition of phospholipase C (PLC).

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
096H0487
083K0591
041H0419
045H1513

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M Takei et al.
Biochemical and biophysical research communications, 181(3), 1313-1322 (1991-12-31)
NCDC dose-dependently inhibited histamine release from rat peritoneal mast cells induced by anti-IgE. Moreover, NCDC inhibited Ca(2+)-mobilization from intracellular Ca(2+)-stores as well as histamine release in mast cells activated by anti IgE, the effect on both of these phenomena being
THE UTILIZATION OF A SPECIFIC CHROMOGENIC INACTIVATOR IN AN "ALL OR NONE" ASSAY FOR CHYMOTRYPSIN.
B F ERLANGER et al.
Biochemistry, 3, 346-349 (1964-03-01)

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