N7251
4-硝基邻苯二酚硫酸盐 二钾盐
chromogenic sulphatase substrate, crystalline
别名:
2-羟基-5-硝基苯硫酸盐, 2-羟基-5-硝基苯硫酸盐 二钾盐 一水合物, 对硝基儿茶酚硫酸盐 二钾盐
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关于此项目
线性分子式:
C6H3NO7SK2
化学文摘社编号:
分子量:
311.35
Beilstein:
3805018
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
一般描述
4-硝基儿茶酚硫酸盐是一种芳香族硫酸盐。
显色硫酸酯酶底物。
应用
4-硝基儿茶酚硫酸二钾盐被用作粘多糖 VI（MPS VI）分析的底物。它也被用来测量糖胺聚糖（GAG）降解酶-芳基磺化酶B和外糖苷酶的活性。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Mazdak Khajehpour et al.
Biochemistry, 46(14), 4370-4378 (2007-03-14)
The Yersinia protein tyrosine phosphatase (YopH) contains a loop of ten amino acids (the WPD loop) that covers the entrance of the active site of the enzyme during substrate binding. In this work the substrate mimicking competitive inhibitor p-nitrocatechol sulfate
M Recksiek et al.
The Journal of biological chemistry, 273(11), 6096-6103 (1998-04-16)
Sulfatases contain an active site formylglycine residue that is generated by post-translational modification. Crystal structures of two lysosomal sulfatases revealed significant similarity to the catalytic site of alkaline phosphatase containing a serine at the position of formylglycine. To elucidate the
C O'Fagain et al.
The Biochemical journal, 201(2), 345-352 (1982-02-01)
A simple model is described to account for the anomalous time course of arylsulphatase A. In the case of the ox liver and human placental enzymes the enzyme-nitrocatechol sulphate complex can, in addition to forming products, slowly break down to
The convulsive effects of dopamine sulfate conjugates in rat brain.
N T Buu et al.
Life sciences, 29(22), 2311-2316 (1981-11-30)
D B Thompson et al.
Experientia, 42(2), 150-151 (1986-02-15)
Rodent and bovine arylsulfatase B hydrolyze 4-methylumbelliferyl sulfate (4MUS) 10- to 30-fold more efficiently than arylsulfatase A. Therefore, 4MUS grossly underestimates arylsulfatase A activity in the presence of excess arylsulfatase B.
商品
Drug conjugate analysis and the enzymatic hydrolysis of glucuronides
实验方案
Enzymatic Assay of Sulfatase (EC 3.1.6.1.)
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