N8278
N-(NBD-Aminohexanoyl)sphingosine
别名:
N-([7-Nitrobenz-2-oxa-1,3-diazol-4-yl]aminocaproyl)sphingosine, NBD hexanoic ceramide
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关于此项目
经验公式（希尔记法）:
C30H49N5O6
化学文摘社编号:
分子量:
575.74
UNSPSC Code:
12352211
PubChem Substance ID:
MDL number:
Form:
powder
form
powder
lipid type
sphingolipids
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCNc1ccc(c2nonc12)N(=O)=O
InChI
1S/C30H49N5O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-27(37)25(23-36)32-28(38)19-16-14-17-22-31-24-20-21-26(35(39)40)30-29(24)33-41-34-30/h15,18,20-21,25,27,31,36-37H,2-14,16-17,19,22-23H2,1H3,(H,32,38)/b18-15+/t25-,27+/m0/s1
InChI key
HZIRBXILQRLFIK-VPZZKNKNSA-N
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
A Loidl et al.
Journal of lipid research, 43(5), 815-823 (2002-04-25)
Sphingomyelinases are important enzymes of signal transduction. They catalyze the hydrolysis of sphingomyelin, giving rise to the intracellular formation of biologically active ceramide and phosphatidylcholine. Here we report on a fluorescence method for the fast and accurate determination of this
Vineet Gupta et al.
Journal of lipid research, 51(4), 866-874 (2009-10-15)
Glucosylceramide synthase (GCS or GlcT-1), converting ceramide to glucosylceramide, is a key enzyme for the synthesis of glycosphingolipids. Due to its diverse roles in physiology and diseases, GCS may be a disease marker and drug target. Current assays for enzymes
Boris Boyanovsky et al.
The Journal of biological chemistry, 278(29), 26992-26999 (2003-05-02)
Ceramide is a bioactive molecule involved in cellular responses to stress and inflammation. The major pathway for ceramide accumulation is via agonist-induced activation of cellular sphingomyelinases. It has also been shown that the ceramide level in circulating low density lipoprotein