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O0266

Obestatin mouse, rat

Name: Obestatin mouse, rat
Brand: SIGMA

synthetic

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关于此项目

经验公式（希尔记法）:

C₁₁₄H₁₇₄N₃₄O₃₁

化学文摘社编号:

869705-22-6

分子量:

2516.81

NACRES:

NA.32

PubChem Substance ID:

329818834

UNSPSC Code:

51111800

MDL number:

MFCD08458632

Biological source:

synthetic

Form:

lyophilized powder

Assay:

≥97% (HPLC)

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biological source

synthetic

assay

≥97% (HPLC)

form

lyophilized powder

color

white

solubility

deionized water: 0.5-1 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc5c[nH]cn5)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O

InChI

1S/C114H174N34O31/c1-12-60(8)93(146-90(157)54-128-111(177)92(59(6)7)147-109(175)81(50-91(158)159)143-108(174)78(46-65-25-17-14-18-26-65)144-110(176)83-29-22-42-148(83)113(179)63(11)132-105(171)80(49-87(120)154)139-97(163)69(116)45-64-23-15-13-16-24-64)112(178)137-71(27-19-20-40-115)101(167)140-76(44-58(4)5)106(172)145-82(55-149)99(165)127-52-88(155)130-61(9)95(161)134-72(34-37-84(117)151)103(169)141-77(47-66-30-32-68(150)33-31-66)107(173)136-73(35-38-85(118)152)102(168)135-74(36-39-86(119)153)104(170)142-79(48-67-51-124-56-129-67)98(164)126-53-89(156)133-70(28-21-41-125-114(122)123)100(166)131-62(10)96(162)138-75(94(121)160)43-57(2)3/h13-18,23-26,30-33,51,56-63,69-83,92-93,149-150H,12,19-22,27-29,34-50,52-55,115-116H2,1-11H3,(H2,117,151)(H2,118,152)(H2,119,153)(H2,120,154)(H2,121,160)(H,124,129)(H,126,164)(H,127,165)(H,128,177)(H,130,155)(H,131,166)(H,132,171)(H,133,156)(H,134,161)(H,135,168)(H,136,173)(H,137,178)(H,138,162)(H,139,163)(H,140,167)(H,141,169)(H,142,170)(H,143,174)(H,144,176)(H,145,172)(H,146,157)(H,147,175)(H,158,159)(H4,122,123,125)/t60-,61-,62-,63-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,92-,93-/m0/s1

InChI key

OJSXICLEROKMBP-FFUDWAICSA-N

Gene Information

mouse ... Ghrl(58991)
rat ... Ghrl(59301)

General description

Obestatin is a 23 amino acid bioactive peptide encoded by the ghrelin gene.

Application

Obestatin has been used to study its effect on serum glucose and enzymatic parameters in rats and used to investigate its effect on plasma acyl-ghrelin and body weight in wistar rat.

Biochem/physiol Actions

Obestatin opposes the action of circulating appetite-inducing hormone-ghrelin and plays a vital role in weight regulation via hindering food intake, jejunal contraction and reducing the body weight. Obestatin mediates its activity by interacting with the G-protein coupled receptor 39 (GPR-39).

Obestatin is an obesity peptide.

Obestatin, an obesity peptide, along with Ghrelin peptides are derived from the same prepropeptide, Ghrelin. In contrast to Ghrelin, Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents.

Physical form

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Other Notes

Lyophilized from 0.1% TFA in H2O

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats.

Wang J

Endocrine, 33(1), 77-83 (2008)

Obestatin protects and reverses nonalcoholic fatty liver disease and its associated insulin resistance in rats via inhibition of food intake, enhancing hepatic adiponectin signaling, and blocking ghrelin acylation.

Eman F Khaleel et al.

Archives of physiology and biochemistry, 125(1), 64-78 (2018-02-13)

This study investigated the ameliorative and protective effects of long-term obestatin administration (80 nmol/kg/ intraperitoneal injection (i.p.)) on the pathogenesis of high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) in rats. Rats (n = 8/group) were divided as control, NAFLD, NAFLD + Simvastatin, NAFLD + obestatin

Obestatin does not activate orphan G protein-coupled receptor GPR39.

Lauwers E

Biochemical and Biophysical Research Communications, 351(1), 21-25 (2006)

Effect of Peripheral Obestatin Infusion on Serum Glucose and some Enzymatic Parameters in rats

Rad M N

Advances in Bioresearch, 7 (3), 38-41 (2016)

Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.

Zhang JV

Science, 310(5750), 996-999 (2005)

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全球贸易项目编号

货号	GTIN
O0266-1MG	04061826285022
O0266-.5MG	04061832820897

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主要文件

Obestatin mouse, rat

synthetic

选择尺寸

关于此项目

属性

biological source

assay

form

color

solubility

shipped in

storage temp.

SMILES string

InChI

InChI key

Gene Information

说明

General description

Application

Biochem/physiol Actions

Physical form

Other Notes

安全信息

存储类别

wgk

flash_point_f

flash_point_c

法规信息

文件

分析证书(COA)

已有该产品？

同行评审论文

全球贸易项目编号

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