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Merck
CN

O0266

Sigma-Aldrich

Obestatin mouse, rat

synthetic

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关于此项目

经验公式（希尔记法）:
C114H174N34O31
化学文摘社编号:
869705-22-6
分子量:
2516.81
MDL编号:
MFCD08458632
UNSPSC代码:
51111800
PubChem化学物质编号:
329818834
NACRES:
NA.32

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生物来源

synthetic

方案

≥97% (HPLC)

表单

lyophilized powder

颜色

white

溶解性

deionized water: 0.5-1 mg/mL

运输

dry ice

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc5c[nH]cn5)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O

InChI

1S/C114H174N34O31/c1-12-60(8)93(146-90(157)54-128-111(177)92(59(6)7)147-109(175)81(50-91(158)159)143-108(174)78(46-65-25-17-14-18-26-65)144-110(176)83-29-22-42-148(83)113(179)63(11)132-105(171)80(49-87(120)154)139-97(163)69(116)45-64-23-15-13-16-24-64)112(178)137-71(27-19-20-40-115)101(167)140-76(44-58(4)5)106(172)145-82(55-149)99(165)127-52-88(155)130-61(9)95(161)134-72(34-37-84(117)151)103(169)141-77(47-66-30-32-68(150)33-31-66)107(173)136-73(35-38-85(118)152)102(168)135-74(36-39-86(119)153)104(170)142-79(48-67-51-124-56-129-67)98(164)126-53-89(156)133-70(28-21-41-125-114(122)123)100(166)131-62(10)96(162)138-75(94(121)160)43-57(2)3/h13-18,23-26,30-33,51,56-63,69-83,92-93,149-150H,12,19-22,27-29,34-50,52-55,115-116H2,1-11H3,(H2,117,151)(H2,118,152)(H2,119,153)(H2,120,154)(H2,121,160)(H,124,129)(H,126,164)(H,127,165)(H,128,177)(H,130,155)(H,131,166)(H,132,171)(H,133,156)(H,134,161)(H,135,168)(H,136,173)(H,137,178)(H,138,162)(H,139,163)(H,140,167)(H,141,169)(H,142,170)(H,143,174)(H,144,176)(H,145,172)(H,146,157)(H,147,175)(H,158,159)(H4,122,123,125)/t60-,61-,62-,63-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,92-,93-/m0/s1

InChI key

OJSXICLEROKMBP-FFUDWAICSA-N

基因信息

mouse ... Ghrl(58991)
rat ... Ghrl(59301)

Amino Acid Sequence

Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2

一般描述

Obestatin is a 23 amino acid bioactive peptide encoded by the ghrelin gene.

应用

Obestatin has been used to study its effect on serum glucose and enzymatic parameters in rats and used to investigate its effect on plasma acyl-ghrelin and body weight in wistar rat.

生化/生理作用

Obestatin is an obesity peptide.
Obestatin opposes the action of circulating appetite-inducing hormone-ghrelin and plays a vital role in weight regulation via hindering food intake, jejunal contraction and reducing the body weight. Obestatin mediates its activity by interacting with the G-protein coupled receptor 39 (GPR-39).
Obestatin, an obesity peptide, along with Ghrelin peptides are derived from the same prepropeptide, Ghrelin. In contrast to Ghrelin, Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents.

外形

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

其他说明

Lyophilized from 0.1% TFA in H2O

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
078M4813V
036M4846V
020M4807
020M4808

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Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats.
Wang J
Endocrine, 33(1), 77-83 (2008)
Obestatin does not activate orphan G protein-coupled receptor GPR39.
Lauwers E
Biochemical and Biophysical Research Communications, 351(1), 21-25 (2006)
Eman F Khaleel et al.
Archives of physiology and biochemistry, 125(1), 64-78 (2018-02-13)
This study investigated the ameliorative and protective effects of long-term obestatin administration (80 nmol/kg/ intraperitoneal injection (i.p.)) on the pathogenesis of high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) in rats. Rats (n = 8/group) were divided as control, NAFLD, NAFLD + Simvastatin, NAFLD + obestatin
Effects of obestatin on energy balance and growth hormone secretion in rodents.
Nogueiras R
Endocrinology, 148(1), 21-26 (2007)
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.
Zhang JV
Science, 310(5750), 996-999 (2005)
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