O0641
Oroxylin A
≥98% (HPLC)
别名:
5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one, 5,7-Dihydroxy-6-methoxyflavone;, 6-Methoxybaicalein;
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关于此项目
经验公式（希尔记法）:
C16H12O5
化学文摘社编号:
分子量:
284.26
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3
SMILES string
COc1c(O)cc2OC(=CC(=O)c2c1O)c3ccccc3
InChI key
LKOJGSWUMISDOF-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
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Biochem/physiol Actions
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. It shows amelioration of Abeta(25-35) peptide-induced memory impairment.
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. The amelioration of Abeta(25-35) peptide-induced memory impairment by oroxylin A is believed to be mediated via the GABAergic neurotransmitter system after a single administration, or by reductions in Abeta(25-35) peptide-induced astrocyte and microglia activations, iNOS expression, lipid peroxidation, and increased cholinergic neurotransmission after subchronic administration.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Chenrui Li et al.
The AAPS journal, 14(1), 23-34 (2011-12-15)
Radix Scutellariae is a commonly used herbal medicine. Baicalein, wogonin, and oroxylin A are three major bioactive flavones in Radix Scutellariae and share similar chemical structures. The intestinal absorption and disposition of baicalein have been systematically investigated by our group
Runzhi Zhu et al.
PloS one, 8(8), e71612-e71612 (2013-08-21)
Based on the previous research that oroxylin A can suppress inflammation, we investigated the hepatoprotective role of oroxylin A against CCl₄-induced liver damage in mice and then studied the possible alteration of the activities of cytokine signaling participating in liver
Hong Wang et al.
PloS one, 8(7), e69555-e69555 (2013-08-08)
Oroxylin A, a natural flavonoid, is one of the main bioactive compounds that underlie the anti-inflammatory effect of the medicinal herb Scutellaria baicalensis Georgi widely used in southeastern Asia; however, the molecular mechanisms for the therapeutic benefits remain largely unclear.
Hui-Ying Yang et al.
Molecular carcinogenesis, 51(2), 185-195 (2011-05-11)
In this study, oroxylin A showed strong reversal potency in BEL7402/5-FU cells and the reversal fold (RF) reached 4.69. Simultaneously, rhodamine-123 accumulation assay and flow cytometry analysis demonstrated oroxylin A could increase drug accumulation. When combined with oroxylin A, 5-FU
Hien-trung Trinh et al.
Acta pharmacologica Sinica, 31(6), 718-724 (2010-05-11)
To explore whether intestinal microflora plays a role in anti-pruritic activity of baicalin, a main constituent of the rhizome of Scutellaria baicalensis (SB). Baicalin was anaerobically incubated with human fecal microflora, and its metabolites, baicalein and oroxylin A, were isolated.
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