O1136
Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse
clone ODC-29, ascites fluid
别名:
Ornithine Decarboxylase Antibody, Ornithine Decarboxylase Antibody - Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse
产品名称
Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse, clone ODC-29, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
ODC-29, monoclonal
mol wt
antigen 53 kDa
contains
15 mM sodium azide
species reactivity
human, mouse
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:100
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ODC1(4953)
mouse ... Odc1(18263)
Application
Monoclonal Anti-Ornithine Decarboxylase (ODC) has also been used in enzyme linked immunosorbent assay (ELISA), immunoprecipitation, immunoblotting and immunohistochemistry.
Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse has been used in Western blotting.
Biochem/physiol Actions
By immunohistochemical staining of formalin-fixed, paraffin-embedded human prostate and colon carcinoma, the labeling is confined to epithelial cells.
Ornithine Decarboxylase (ODC) biological activity is rapidly induced to promote cell proliferation in response to hormones, drugs, growth factors, mitogens and tumour promoters. ODC mRNA levels are also elevated in transformed cells including lung carcinomas and human colon adenomas and carcinomas. ODC activity in colorectal carcinomas has been shown to be greater than that in adenomas, which, in turn, is greater than that of normal mucosa. ODC has a half-life of 8-30 min, the shortest half-life time reported in eukaryotic cells.
Ornithine decarboxylase (ODC) converts L-ornithine to putrescine. It has a role in cell replication. ODC is also involved in the polyamine synthesis pathway. The protein is upregulated in cancers. Overexpression of ODC has been associated with carcinogenesis in mice.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Ornithine Decarboxylase (ODC) (mouse IgG2b isotype) is derived from the ODC-29 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Its amino acid sequence is well conserved among species; the overall identity of the amino acid sequences of mouse, rat and human ODC proteins is greater than 90%.
Ornithine decarboxylase (ODC) levels increase rapidly after implantation during mouse embryogenesis. The gene encoding this protein is localized on mouse chromosome 12 and human chromosome 2.
Immunogen
recombinant mouse ornithine decarboxylase.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
动植物来源生物产品
此项目有
The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth
David Bernard
Oncogene, 25, 1358?1366-1358?1366 (2006)
Ornithine Decarboxylase (ODC) Expression Pattern in Human Prostate Tissues and ODC Transgenic Mice
Lei Young
The Journal of Histochemistry and Cytochemistry, 54(2) (2006)
Myc confers androgen-independent prostate cancer cell growth
David Bernard
The Journal of Clinical Investigation, 112(11), 1724?1731-1724?1731 (2003)
Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene
Noreen J
Gene, 93(2), 257-263 (1990)
Ornithine decarboxylase activity is required for prostatic budding in the developing mouse prostate
Gamat M, et al.
PLoS ONE, 10(10), e0139522-e0139522 (2015)
相关内容
Datasheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持