O2264
ONO-1301
≥98% (HPLC)
别名:
7,8-Dihydro-5-[(E)-[[α-(3-pyridyl)benzylidene]aminooxy]ethyl]-1-naphthyloxy]acetic acid
方案
≥98% (HPLC)
组成
Mixture of E and Z isomers
颜色
white
mp
147-158 °C (lit.)
溶解性
DMSO: 18 mg/mL
储存温度
−20°C
SMILES字符串
OC(=O)COc1cccc2C(CCO\N=C(/c3ccccc3)c4cccnc4)=CCCc12
InChI
1S/C26H24N2O4/c29-25(30)18-31-24-13-5-11-22-19(9-4-12-23(22)24)14-16-32-28-26(20-7-2-1-3-8-20)21-10-6-15-27-17-21/h1-3,5-11,13,15,17H,4,12,14,16,18H2,(H,29,30)/b28-26+
InChI key
WBBLIRPKRKYMTD-BYCLXTJYSA-N
基因信息
human ... PTGIR(5739), TBXA2R(6915)
生化/生理作用
Non-prostanoid prostacyclin mimetic; IP receptor agonist with weak EP3 agonist activity.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Shinsuke Murakami et al.
American journal of physiology. Lung cellular and molecular physiology, 290(1), L59-L65 (2005-09-13)
The balance between prostacyclin and thromboxane A2 (TXA2) plays an important role in pulmonary homeostasis. However, little information is available regarding the therapeutic potency of these prostanoids for pulmonary fibrosis. We have recently developed ONO-1301, a novel long-acting prostacyclin agonist
Mai Hazekawa et al.
Journal of microencapsulation, 29(3), 211-218 (2012-03-01)
The purpose of this study was to prepare the ONO-1301 loaded poly(lactide-co-glycolide) microsphere (ONO-1301 PLGA MS) and to evaluate neuroprotective effects for short-term memory by a single subcutaneous injection of ONO-1301 PLGA MS on repeated induction of cerebral ischemia (2 × 10-min
Yoichiro Hirata et al.
European journal of pharmacology, 699(1-3), 81-87 (2012-12-12)
Injury to the heart can result in cardiomyocyte hypertrophy, fibrosis, and cell death. Myocarditis sometimes progresses to dilated cardiomyopathy. We previously reported that ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase inhibitory activity, promotes production of hepatocyte growth factor (HGF) from
Jun-ichi Suzuki et al.
International heart journal, 53(1), 64-67 (2012-03-09)
ONO-1301MS is a compound that acts as a prostacyclin agonist with thromboxane A2 synthase inhibitory activity. We investigated the effect of ONO-1301MS on myocardial remodeling in murine cardiac allografts. The hearts of Balb/c mice were transplanted into C3H/He mice (a
Kazuto Nakamura et al.
Clinical science (London, England : 1979), 112(12), 607-616 (2007-02-01)
It has been shown previously that administration of angiogenic growth factors as genes or proteins can augment collateral growth in ischaemic tissues. In the present study, we have investigated the effect of ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase-inhibitory activity
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