O2264
ONO-1301
≥98% (HPLC)
别名:
7,8-Dihydro-5-[(E)-[[α-(3-pyridyl)benzylidene]aminooxy]ethyl]-1-naphthyloxy]acetic acid
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关于此项目
经验公式（希尔记法）:
C26H24N2O4
化学文摘社编号:
分子量:
428.48
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C26H24N2O4/c29-25(30)18-31-24-13-5-11-22-19(9-4-12-23(22)24)14-16-32-28-26(20-7-2-1-3-8-20)21-10-6-15-27-17-21/h1-3,5-11,13,15,17H,4,12,14,16,18H2,(H,29,30)/b28-26+
SMILES string
OC(=O)COc1cccc2C(CCO\N=C(/c3ccccc3)c4cccnc4)=CCCc12
InChI key
WBBLIRPKRKYMTD-BYCLXTJYSA-N
assay
≥98% (HPLC)
composition
Mixture of E and Z isomers
color
white
mp
147-158 °C (lit.)
solubility
DMSO: 18 mg/mL
storage temp.
−20°C
Gene Information
human ... PTGIR(5739), TBXA2R(6915)
Biochem/physiol Actions
Non-prostanoid prostacyclin mimetic; IP receptor agonist with weak EP3 agonist activity.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats.
Hiroaki Obata et al.
American journal of respiratory and critical care medicine, 177(2), 195-201 (2007-11-03)
Although prostacyclin is recognized as a therapeutic breakthrough for pulmonary hypertension, it needs continuous infusion because of its short action. Therefore, we developed a new drug delivery system for prostacyclin. We prepared ONO-1301MS, a novel sustained-release prostacyclin analog polymerized with
Hiroshi Iwata et al.
Life sciences, 85(5-6), 255-261 (2009-06-17)
It was reported that administration of angiogenic growth factors can augment collateral growth in ischemic tissues. It is assumed that angiogenic effects of cell transplantation may be mainly mediated by secretion of angiogenic cytokines. We tested feasibility of clinical use
Cristiane Yamabayashi et al.
American journal of respiratory cell and molecular biology, 47(2), 170-177 (2012-03-10)
Airway remodeling in bronchial asthma results from chronic, persistent airway inflammation. The effects of the reversal of airway remodeling by drug interventions remain to be elucidated. We investigated the effects of ONO-1301, a novel prostacyclin agonist with thromboxane inhibitory activity
Qing Xu et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(4), G420-G429 (2011-12-14)
Previous studies have demonstrated that mice disrupted with the cyclooxygenase-2 gene showed much more severe liver damage compared with wild-type mice after liver injury, and prostaglandins (PGs) such as PGE(1/2) and PGI(2) have decreased hepatic injury, but the mechanisms by
Yoichiro Hirata et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 63(10), 781-786 (2009-11-13)
Impairment of cardiac function in cardiomyopathy has been postulated to be related to decreased blood flow and increased collagen synthesis. Administration of growth factors was reported to attenuate left ventricular (LV) remodeling and dysfunction in animal models of dilated cardiomyopathy.
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