O2627
毒毛花苷
≥95%
别名:
1β,3β,5,11α,14,19-Hexahydroxy-5β-card-20(22)-enolide, G-Strophanthidin
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关于此项目
经验公式（希尔记法）:
C23H34O8
化学文摘社编号:
分子量:
438.51
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
产品名称
毒毛花苷, ≥95%
InChI
1S/C23H34O8/c1-20-9-16(26)19-15(23(20,30)5-3-14(20)12-6-18(28)31-10-12)2-4-21(29)8-13(25)7-17(27)22(19,21)11-24/h6,13-17,19,24-27,29-30H,2-5,7-11H2,1H3/t13-,14+,15+,16+,17+,19+,20+,21-,22+,23-/m0/s1
SMILES string
[H][C@@]12CC[C@]3(O)C[C@@H](O)C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]4(C)[C@H](CC[C@]24O)C5=CC(=O)OC5
InChI key
BXSABLKMKAINIU-QOHCMMFCSA-N
assay
≥95%
storage temp.
2-8°C
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Biochem/physiol Actions
Ouabagenin exerts cardiotonic effects through inhibition of Na+/K+-ATPase like the glycosides, albeit at significantly lower potency.
General description
The aglycone of the cardiac glycoside ouabain.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 3 Inhalation - STOT RE 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Iodoacetylated ouabagenins: their syntheses, spectroscopic characterizations, and stability studies.
M Chatterjee et al.
Steroids, 60(6), 477-483 (1995-06-01)
Ouabain shows high binding ability to myocardial Na+,K(+)-ATPase and, therefore, a suitably radiolabeled derivative of this compound may find use in myocardial imaging. In this pilot experiment we report the preparation of several chloroacetylated and iodoacetylated ouabagenins. These intermediates may
J G Dong et al.
Enantiomer, 2(5), 397-409 (1997-01-01)
Ample experimental evidence shows that the principle of pairwise additivity holds in exciton coupled CD systems consisting of three or more interacting chromophores. This principle is one of the most important from a practical viewpoint. However, the rule has so
D Bose et al.
Canadian journal of physiology and pharmacology, 66(9), 1232-1238 (1988-09-01)
Scattered light intensity fluctuation (SLIF) of coherent light by a strip of ventricular muscle during diastole is believed to be due to asynchronous cellular motion within the myocyte as a result of spontaneous release of Ca from the sacoplamic reticulum.
H Núñez-Durán et al.
The American journal of physiology, 255(4 Pt 1), C479-C485 (1988-10-01)
Mammalian cells specifically internalize some molecular species through receptor-mediated endocytosis (RME). We have used four different experimental protocols to investigate whether ouabain enters cardiac cells of guinea pig atrium through this pathway. First, by electron microscope morphometry we found that
J F Templeton et al.
Journal of medicinal chemistry, 30(8), 1502-1505 (1987-08-01)
The synthesis of 14-hydroxy-14 beta-pregn-4-ene-3,20-dione (14 beta-hydroxyprogesterone) is described. This novel steroid is about 10 times more potent than progesterone and one-tenth as potent as ouabagenin in an [3H]ouabain radioligand binding assay and is the first in a series of
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