O2627
毒毛花苷
≥95%
别名:
1β,3β,5,11α,14,19-Hexahydroxy-5β-card-20(22)-enolide, G-Strophanthidin
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关于此项目
经验公式（希尔记法）:
C23H34O8
化学文摘社编号:
分子量:
438.51
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C23H34O8/c1-20-9-16(26)19-15(23(20,30)5-3-14(20)12-6-18(28)31-10-12)2-4-21(29)8-13(25)7-17(27)22(19,21)11-24/h6,13-17,19,24-27,29-30H,2-5,7-11H2,1H3/t13-,14+,15+,16+,17+,19+,20+,21-,22+,23-/m0/s1
SMILES string
[H][C@@]12CC[C@]3(O)C[C@@H](O)C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]4(C)[C@H](CC[C@]24O)C5=CC(=O)OC5
InChI key
BXSABLKMKAINIU-QOHCMMFCSA-N
assay
≥95%
storage temp.
2-8°C
General description
The aglycone of the cardiac glycoside ouabain.
Biochem/physiol Actions
Ouabagenin exerts cardiotonic effects through inhibition of Na+/K+-ATPase like the glycosides, albeit at significantly lower potency.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 3 Inhalation - STOT RE 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Total synthesis of ouabagenin and ouabain.
Hongxing Zhang et al.
Angewandte Chemie (International ed. in English), 47(7), 1272-1275 (2008-01-10)
M B Pamnani et al.
Hypertension (Dallas, Tex. : 1979), 18(3), 316-324 (1991-09-11)
Reports from several laboratories suggest the presence of an ouabainlike compound in plasma and various animal tissues, particularly during acute volume expansion and in low-renin hypertension. It has been hypothesized that this compound, through inhibition of the Na(+)-K+ pump, can
T L Chan et al.
The Canadian journal of cardiology, 3(4), 197-204 (1987-05-01)
The mechanism of cardiac oscillatory activity induced by digitalis was studied in the canine ventricular muscle. We determined the role of sarcoplasmic reticulum in the phenomenon of oscillatory afterpotential and mechanical aftercontractions. Additionally we wished to study the interaction between
Maddi Sridhar Reddy et al.
Chemistry, an Asian journal, 4(5), 725-741 (2009-03-19)
A full account of the total synthesis of ouabagenin and ouabain is described. A highly stereocontrolled anionic cycloaddition for the rapid construction of the basic steroid skeleton is a pivotal conversion for the whole strategy. A careful study was needed
H Núñez-Durán et al.
The American journal of physiology, 255(4 Pt 1), C479-C485 (1988-10-01)
Mammalian cells specifically internalize some molecular species through receptor-mediated endocytosis (RME). We have used four different experimental protocols to investigate whether ouabain enters cardiac cells of guinea pig atrium through this pathway. First, by electron microscope morphometry we found that
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