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About This Item

线性分子式:
C22H24N2O9 · 1/2Ca
CAS Number:
15251-48-6
分子量:
480.47
EC 号:
239-293-7
MDL编号:
MFCD00151362
UNSPSC代码:
51101500
PubChem化学物质编号:
24897968
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溶解性

formic acid: 50 mg/mL, very slightly hazy, orange to very deep orange

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

[Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)C3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1[O-])C(=O)c4c(O)cccc4[C@@]3(C)O.CN(C)[C@H]5[C@@H]6[C@@H](O)C7C(=C(O)[C@]6(O)C(=O)C(C(N)=O)=C5[O-])C(=O)c8c(O)cccc8[C@@]7(C)O

InChI

1S/2C22H24N2O9.Ca/c2*1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h2*4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);/q;;+2/p-2/t2*12?,13-,14+,17+,21-,22+;/m11./s1

InChI key

KIPLYOUQVMMOHB-JOFVZRTQSA-L

一般描述

Chemical structure: tetracycline

应用

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). It is used for fluorescence measurements of hepatocytes.

生化/生理作用

Oxytetracycline inhibits translation which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Warning

危险声明

H361d,H411

危险分类

Aquatic Chronic 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
050H0142

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