O2881
盐酸奥昔布宁
≥98% (TLC), Muscarinic acetylcholine receptor antagonist, powder
别名:
α-苯基环己烷乙醇酸 4-(二乙基氨基)-2-丁炔酯 盐酸盐
产品名称
盐酸奥昔布宁, ≥98% (TLC), powder
质量水平
方案
≥98% (TLC)
表单
powder
颜色
white
溶解性
H2O: 50 mg/mL
创始人
Johnson & Johnson
SMILES字符串
Cl.CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c2ccccc2
InChI
1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20;/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;1H
InChI key
SWIJYDAEGSIQPZ-UHFFFAOYSA-N
基因信息
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
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相关类别
生化/生理作用
毒蕈碱型乙酰胆碱受体拮抗剂。
毒蕈碱型乙酰胆碱受体拮抗剂；可能通过下调生长促进基因，抑制膀胱平滑肌细胞的增殖。
特点和优势
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Naoki Aizawa et al.
European urology, 62(6), 1165-1173 (2012-09-18)
Mirabegron is the first β3-adrenoceptor agonist that is clinically effective for overactive bladder. The effects of mirabegron on primary bladder mechanosensitive single-unit afferent activities (SAAs) and bladder microcontractions were evaluated and compared with the effects of oxybutynin. Female Sprague-Dawley rats
Diane K Newman et al.
Urologic nursing, 32(5), 265-269 (2013-03-12)
This study determined the median drying time for oxybutynin chloride topical gel (OTG) approved for treatment of overactive bladder was 3.1 minutes, Most participants reported positive perceptions of OTG attributes.
Jessica T Casey et al.
The Journal of urology, 188(4 Suppl), 1516-1520 (2012-08-23)
Abnormal bladder function following posterior urethral valve ablation can lead to deleterious effects on renal function and urinary continence. We performed a pilot study to determine if bladder dysfunction could be ameliorated by the early administration of oxybutynin. We enrolled
V Schuler et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(10), 947-951 (2012-07-25)
A broad spectrum of synthetic agents is available for the treatment of overactive bladder. Anti-cholinergic drugs show a poor compliance due to side effects. There is an increasing use of plant extracts in medicine. We have therefore investigated the inhibitory
Michael H Johnson et al.
The Journal of urology, 189(4), 1268-1274 (2012-11-06)
Intravesical bacillus Calmette-Guérin is used to decrease recurrence rates of nonmuscle invasive urothelial carcinoma. Irritative urinary symptoms are a common side effect of treatment and frequently limit treatment tolerance. While anticholinergic medications may be used for symptom prophylaxis, to our
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