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Merck
CN

O7389

Olprinone hydrochloride

≥98% (HPLC), solid

别名:

1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride, Loprinone hydrochloride

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关于此项目

经验公式（希尔记法）:
C14H10N4O · HCl
化学文摘社编号:
119615-63-3
分子量:
286.72
NACRES:
NA.77
PubChem Substance ID:
24724566
UNSPSC Code:
41106305
MDL number:
MFCD01749474
Assay:
≥98% (HPLC)
Form:
solid

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InChI

1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H

SMILES string

Cl[H].CC1=C(C=C(C#N)C(=O)N1)c2ccc3nccn3c2

InChI key

PWTBMBAQRAOAFF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

beige

solubility

DMSO: ≤4 mg/mL, H2O: 6.8 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Selective phosphodiesterase 3 (PDE3) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
056K47151
056K4715

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Tiziana Genovese et al.
Neuroscience letters, 503(2), 93-99 (2011-08-30)
Olprinone hydrochloride, a specific phosphodiesterase III inhibitor, has anti-inflammatory effects in addition to its inotropic and vasodilatory effects. The purpose of this study was to examine the beneficial effects of olprinone on cerebral ischemia reperfusion injury. In the present study
[Protection from pulmonary apoptosis: a new therapeutic choice for septic acute lung injury].
Ken-ichi Takano et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 138(4), 146-150 (2011-10-12)
Controlled reperfusion.
Hajime Ichikawa
General thoracic and cardiovascular surgery, 60(2), 65-67 (2012-02-14)
Daniela Mokra et al.
Pulmonary pharmacology & therapeutics, 25(3), 216-222 (2012-03-06)
Since inflammation and oxidation play a key role in the pathophysiology of neonatal meconium aspiration syndrome, various anti-inflammatory drugs have been tested in the treatment. This study evaluated whether the phosphodiesterase (PDE) 3 inhibitor olprinone can alleviate meconium-induced inflammation and
Emanuela Mazzon et al.
Pharmacological research, 64(1), 68-79 (2011-01-05)
Olprinone is a specific phosphodiesterase (PDE)-III inhibitor, which has been found to have anti-inflammatory effects in addition to its main inotropic and peripheral vasodilatory effects. In the present study we investigated the effects of olprinone (0.2mg/kg, i.p.) on the development
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Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

磷酸二酯酶类

环核苷酸磷酸二酯酶 (PDEs) 催化 cAMP 和/或 cGMP 的水解。存在有11种不同的哺乳动物PDE家族。

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