O9262
1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine
≥99% (TLC), waxy solid
别名:
ET-18-OCH3
方案
≥99% (TLC)
表单
waxy solid
颜色
white
溶解性
ethanol: soluble 15 mg/mL at 45 °C
chloroform: soluble >25 mg/mL
DMSO: soluble
运输
wet ice
储存温度
−20°C
SMILES字符串
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC)COCCCCCCCCCCCCCCCCCC)=O
InChI
1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3/t27-/m1/s1
InChI key
MHFRGQHAERHWKZ-HHHXNRCGSA-N
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生化/生理作用
Phosphoinositide-specific phospholipase C (PI-PLC) inhibitor.
特点和优势
This compound is featured on the Phospholipase C page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
制备说明
1-O-Octadecyl-2-O-methyl-sn-glycero-3- phosphorylcholine is soluble in ethanol at 15 mg/ml and in chloroform at 25 mg/ml.
The following steps are for the preparation of a DMSO stock solution.
1. Solubilize 1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine in chloroform.
2. Deposit a thin film of the compound on the sides of a container by evaporating the chloroform with a stream of nitrogen or argon.
3. Add DMSO and vortex mix to dissolve the compound from the sides of the container. The DMSO or ethanol solutions may be diluted at least 1000-fold directly into stirred aqueous cell culture medium.
The following steps are for the preparation of a DMSO stock solution.
1. Solubilize 1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine in chloroform.
2. Deposit a thin film of the compound on the sides of a container by evaporating the chloroform with a stream of nitrogen or argon.
3. Add DMSO and vortex mix to dissolve the compound from the sides of the container. The DMSO or ethanol solutions may be diluted at least 1000-fold directly into stirred aqueous cell culture medium.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
I Baburina et al.
The Journal of biological chemistry, 273(4), 2169-2173 (1998-01-27)
A HeLa cell line was constructed for the regulation of CTP:phosphocholine cytidylyltransferase (CCT) expression via a tetracycline-responsive promoter to test the role of CCT in apoptosis triggered by exposure of cells to the antineoplastic phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3). Basal CCT expression
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