P0021
Pantoprazole sodium hydrate
≥98% (HPLC), gastric proton pump inhibitor, powder
别名:
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate
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关于此项目
经验公式（希尔记法）:
C16H14F2N3O4S · Na · xH2O
化学文摘社编号:
分子量:
405.35 (anhydrous basis)
UNSPSC Code:
12352203
PubChem Substance ID:
NACRES:
NA.77
产品名称
Pantoprazole sodium hydrate, ≥98% (HPLC)
SMILES string
O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
InChI
1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;
InChI key
CGJRLPRCWSHOFU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
color
white to off-white
solubility
H2O: ≥20 mg/mL
originator
Novartis
storage temp.
−20°C
Quality Level
Gene Information
human ... ATP4A(495), ATP4B(496)
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Application
Pantoprazole sodium hydrate has been used:
- as a standard in high-performance liquid chromatography (HPLC){58
- as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
- to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines
Biochem/physiol Actions
Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.
Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.
Pantoprazole is a gastric proton pump inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Pantoprazole
<BIG>Perry CM and Ibbotson T</BIG>
Drugs, 101-132 (2003)
Analysis of ibuprofen, pantoprazole, and itopride combination therapeutic drugs in human plasma by solid phase membrane microtip extraction and high-performance liquid chromatography methods using new generation core shell C18 column
Ali I, et al.
Journal of Liquid Chromatography and Related Technologies, 39(7), 339-345 (2016)
<BIG>Rissling O</BIG>
Interaction of Mycophenolic Acid and Pantoprazole: A Pharmacokinetic Crossover Study (2017)
Khamushavalli Geeviman et al.
Cellular and molecular neurobiology, 38(8), 1491-1504 (2018-10-12)
Gastric H+/K+-ATPase or vacuolar-ATPases (V-ATPases) are critical for the cancer cells survival and growth in the ischemic microenvironment by extruding protons from the cell. The drugs which inhibit V-ATPases are known as proton pump inhibitors (PPIs). In the present study
Maryam H Shubbar et al.
European journal of pharmacology, 874, 173009-173009 (2020-02-18)
Deposition of amyloid-β peptide (Aβ(1-42)) is a hallmark of Alzheimer's disease. Clearance of Aβ(1-42), across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little is known of the effect
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