P0021
Pantoprazole sodium hydrate
≥98% (HPLC), gastric proton pump inhibitor, powder
别名:
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate
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关于此项目
经验公式（希尔记法）:
C16H14F2N3O4S · Na · xH2O
化学文摘社编号:
分子量:
405.35 (anhydrous basis)
UNSPSC Code:
12352203
PubChem Substance ID:
NACRES:
NA.77
产品名称
Pantoprazole sodium hydrate, ≥98% (HPLC)
SMILES string
O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
InChI
1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;
InChI key
CGJRLPRCWSHOFU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white to off-white
solubility
H2O: ≥20 mg/mL
originator
Novartis
storage temp.
−20°C
Quality Level
Gene Information
human ... ATP4A(495), ATP4B(496)
Application
Pantoprazole sodium hydrate has been used:
- as a standard in high-performance liquid chromatography (HPLC){58
- as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
- to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines
Biochem/physiol Actions
Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.
Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.
Pantoprazole is a gastric proton pump inhibitor.
Features and Benefits
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A Fitton et al.
Drugs, 51(3), 460-482 (1996-03-01)
Pantoprazole is an irreversible proton pump inhibitor which, at the therapeutic dose of 40mg, effectively reduces gastric acid secretion. In controlled clinical trials, pantoprazole (40mg once daily) has proved superior to ranitidine (300mg once daily or 150mg twice daily) and
Pantoprazole
<BIG>Perry CM and Ibbotson T</BIG>
Drugs, 101-132 (2003)
Analysis of ibuprofen, pantoprazole, and itopride combination therapeutic drugs in human plasma by solid phase membrane microtip extraction and high-performance liquid chromatography methods using new generation core shell C18 column
Ali I, et al.
Journal of Liquid Chromatography and Related Technologies, 39(7), 339-345 (2016)
<BIG>Rissling O</BIG>
Interaction of Mycophenolic Acid and Pantoprazole: A Pharmacokinetic Crossover Study (2017)
Maryam H Shubbar et al.
European journal of pharmacology, 874, 173009-173009 (2020-02-18)
Deposition of amyloid-β peptide (Aβ(1-42)) is a hallmark of Alzheimer's disease. Clearance of Aβ(1-42), across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little is known of the effect
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