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P0026

Sigma-Aldrich

吡西卡尼 盐酸盐

≥98% (HPLC)

别名:

N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide hydrochloride, Pilzicainide hydrochloride, SUN 1165

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CN¥839.36
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5 G
CN¥839.36
25 G
CN¥2,470.71
100 G
CN¥6,170.48

About This Item

经验公式（希尔记法）:
C17H24N2O · xHCl
CAS Number:
88069-49-2
分子量:
272.39 (free base basis)
MDL编号:
MFCD00903769
UNSPSC代码:
12352200
PubChem化学物质编号:
329819981
NACRES:
NA.77

CN¥839.36

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质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

deionized water: >5 mg/mL

储存温度

room temp

SMILES字符串

Cl.Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3

InChI

1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H

InChI key

NZOSVDHCTCLGEB-UHFFFAOYSA-N

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271748P6155P9130
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Pyridoxal hydrochloride

Pyridoxal hydrochloride BioReagent, suitable for cell culture, suitable for insect cell culture

P6155

Pyridoxal hydrochloride

Pyridoxal hydrochloride ≥99% (HPLC)

P9130

Pyridoxal hydrochloride

biological source

synthetic

biological source

synthetic (Organic)

biological source

-

biological source

synthetic (organic)

assay

≥99.5% (T)

assay

99%

assay

≥99% (HPLC)

assay

≥99% (HPLC)

form

powder

form

powder

form

powder

form

powder

application(s)

cell analysis

application(s)

-

application(s)

-

application(s)

-

color

white to faint beige

color

white to off-white

color

white to off-white

color

white to off-white

mp

173 °C (dec.) (lit.)

mp

173 °C (dec.) (lit.)

mp

173 °C (dec.) (lit.)

mp

173 °C (dec.) (lit.)

应用

Pilsicainide hydrochloride has been used as a sodium channel blocker:
  • to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation[1]
  • to study its effects on Ca2+ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes[2]
  • to study its electrophysiological effects on the guinea pig atrium[3]

生化/生理作用

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels.
Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    042M4739V
    0000136912
    0000136911
    0000109351
    0000091576

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    访问文档库

    Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells
    Yeung SYM and Greenwood IA
    British Journal of Pharmacology, 146(4), 585-595 (2005)
    Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel
    Thompson J and Begenisich T
    The Journal of General Physiology, 127(2), 159-169 (2006)
    Conservation of lipid metabolic gene transcriptional regulatory networks in fish and mammals
    Carmona-Antonanzas, Greta and Tocher, Douglas R and Martinez-Rubio, Laura and Leaver, Michael J
    Gene, 534(1), 1-9 (2014)
    Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
    Zhou Y and Lingle CJ
    The Journal of General Physiology, 144(5), 415-440 (2014)
    Contribution of the functional coupling between the human myometrial beta2-adrenoreceptor and the BKCa channel to uterine quiescence
    Chanrachakul B, et al.
    American Journal of Physiology. Cell Physiology, 287(C1747?C1752), 585-595 (2004)
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