Anti-p190-B RhoGAP (C-terminal region) antibody produced in rabbit

Rho GTPase activating protein 5 (ARHGAP5) or p190-B RhoGAP is a member of the RhoGTPase activating protein (RhoGAP family). ARHGAP5 gene is mapped to human chromosome 14q12 and is protumorigenic. p190-A and p190-B are the two isoforms that are highly expressed in the embryonic and adult brain.

Anti-p190-B RhoGAP (C-terminal region) antibody produced in rabbit may be used in immunoblotting.

Anti-p190-B RhoGAP (C-terminal region) specifically recognizes rat and mouse p190-B RhoGAP.

Rho GTPase activating protein 5 (ARHGAP5) or p190-B RhoGAP functions as negative regulator of Rho activity. Deletion of p190-B in mice results in axonal-tract deficits and neuronal differentiation defects, indicating a central role of p190-B in normal brain development. Also, p190-B-deficient mice are reduced in size due to impaired insulin and insulin-like growth factors (IGF) signaling that affect adipogenesis. Several studies indicate a critical interaction between p190-B and IGF signaling pathway during embryonic mammary morphogenesis and epithelial progenitor cell migration. p190-B has shown to regulate the expression of membrane-type 1-matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase 2 (MMP2) in endothelial cells and in modulating matrix remodeling and angiogenesis processes. It displays a elevated expression in hepatocellular cancer and promotes tumor spreading.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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