Anti-POT1 兔抗

POT1 (Protection of Telomere 1, also known as POTE1and POT1-like telomere end-binding protein) is a highly conserved single-strand telomeric binding protein and is required for both chromosomal end protection and telomere length regulation.

POT1 (Protection of Telomere 1, also known as POTE1 and POT1-like telomere end-binding protein) is a highly conserved single-strand telomeric binding protein. POT1 is one of the six core telomere-binding proteins termed the telosome2 or shelterin. POT1 has eukaryotic homologs and first identified in S. pombe. Mice that carry two POT1 genes encoding two proteins (POT1a and POT1b). Human genome contains one gene that encodes four alternative splice variants (v2, v3, v4, and v5).

Anti-POT1 antibody produced in rabbit has been used in immunoblotting.

Protection of Telomere 1 (POT1) binds single-stranded telomeric DNA through two NH2-terminal oligonucleotide-binding folds and interacts with TTP1 through the COOH-terminal region. It is required for both chromosomal end protection and telomere length regulation. Genetic disruption of the two POT1 genes in mice revealed two different phenotypes. Knockout of Pot1a alone results in embryonic lethality. Pot1a/b double knockout cells showed enhanced telomere dysfunction induced foci.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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