P0105
PM-20
≥96% (HPLC), solid
别名:
1-[1,1′-biphenyl]-4-yl-3,4-bis[(2-hydroxyethyl)thio]-1H-Pyrrole-2,5-dione
InChI key
RFZCIUONZTUZER-UHFFFAOYSA-N
InChI
1S/C20H19NO4S2/c22-10-12-26-17-18(27-13-11-23)20(25)21(19(17)24)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,22-23H,10-13H2
SMILES string
OCCSC1=C(SCCO)C(=O)N(C1=O)c2ccc(cc2)-c3ccccc3
assay
≥96% (HPLC)
form
solid
color
yellow
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
PM-20 is a Cdc25A phosphatase inhibitor.
Disclaimer
air sensitive
Irina V Chikalovets et al.
Fish & shellfish immunology, 42(2), 503-507 (2014-12-09)
Lectins (carbohydrate-binding proteins) are well known to actively participate in the defense functions of vertebrates and invertebrates where they play an important role in the recognition of foreign particles. In this study, we investigated of in vitro antifungal activity of
Siddhartha Kar et al.
Molecular cancer therapeutics, 5(6), 1511-1519 (2006-07-05)
We have synthesized several new phenyl maleimide compounds, which are potent growth inhibitors of several human tumor cell lines. Among these, PM-20 was the most potent with an IC50 of 700 nmol/L for Hep3B human hepatoma cell growth. Two other
Joon-Khim Loh et al.
BMC cancer, 10, 268-268 (2010-06-10)
High-grade gliomas have poor prognosis, requiring aggressive treatment. The aim of this study is to explore mitotic and centrosomal dysregulation in gliomas, which may provide novel targets for treatment. A case-control study was performed using 34 resected gliomas, which were
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