P0105
PM-20
≥96% (HPLC), solid
别名:
1-[1,1′-biphenyl]-4-yl-3,4-bis[(2-hydroxyethyl)thio]-1H-Pyrrole-2,5-dione
方案
≥96% (HPLC)
表单
solid
颜色
yellow
溶解性
DMSO: >10 mg/mL
储存温度
−20°C
SMILES字符串
OCCSC1=C(SCCO)C(=O)N(C1=O)c2ccc(cc2)-c3ccccc3
InChI
1S/C20H19NO4S2/c22-10-12-26-17-18(27-13-11-23)20(25)21(19(17)24)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,22-23H,10-13H2
InChI key
RFZCIUONZTUZER-UHFFFAOYSA-N
生化/生理作用
PM-20 is a Cdc25A phosphatase inhibitor.
免责声明
air sensitive
Joon-Khim Loh et al.
BMC cancer, 10, 268-268 (2010-06-10)
High-grade gliomas have poor prognosis, requiring aggressive treatment. The aim of this study is to explore mitotic and centrosomal dysregulation in gliomas, which may provide novel targets for treatment. A case-control study was performed using 34 resected gliomas, which were
Siddhartha Kar et al.
Molecular cancer therapeutics, 5(6), 1511-1519 (2006-07-05)
We have synthesized several new phenyl maleimide compounds, which are potent growth inhibitors of several human tumor cell lines. Among these, PM-20 was the most potent with an IC50 of 700 nmol/L for Hep3B human hepatoma cell growth. Two other
Irina V Chikalovets et al.
Fish & shellfish immunology, 42(2), 503-507 (2014-12-09)
Lectins (carbohydrate-binding proteins) are well known to actively participate in the defense functions of vertebrates and invertebrates where they play an important role in the recognition of foreign particles. In this study, we investigated of in vitro antifungal activity of
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