P0248
PNU-37883A
≥98% (HPLC), powder
别名:
N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride
方案
≥98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: ~23 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5
基因信息
human ... KCNJ8(3764)
生化/生理作用
Selective inhibitor of Kir6.1/SUR2B channels.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H C Champion et al.
Peptides, 22(9), 1427-1434 (2001-08-22)
Responses to human calcitonin gene-related peptide (hCGRP) and human adrenomedullin (hADM) hAmylin were investigated in isolated mesenteric resistance arteries from the rat. The results of the present investigation show that hCGRP, hAmylin, and hADM induce dose-related vasodilator responses in isolated
Julia Rivo et al.
Anesthesiology, 101(5), 1153-1159 (2004-10-27)
A3 adenosine receptor (AR) activation worsens or protects against renal and cardiac ischemia-reperfusion (IR) injury, respectively. The aims of the current study were to examine in an in vivo model the effect of A3AR activation on IR lung injury and
Toshihisa Tomoda et al.
European journal of pharmacology, 524(1-3), 1-10 (2005-10-26)
The effects of U-37883A, a vascular ATP-sensitive K(+) channel (K(ATP) channel) blocker, on membrane currents were investigated in pig urethral myocytes by use of patch-clamp techniques (conventional whole-cell recordings, nystatin-perforated patches and cell-attached configuration). Tension measurement was also performed to
Yoshihiro Suzuki et al.
International journal of oncology, 41(2), 465-475 (2012-05-23)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, drugs that can amplify TRAIL cytotoxicity
Yi-Ling Chan et al.
Critical care medicine, 40(4), 1261-1268 (2012-03-20)
Excessive opening of the adenosine triphosphate-sensitive potassium channel in vascular smooth muscle is implicated in the vasodilation and vascular hyporeactivity underlying septic shock. Therapeutic channel inhibition using sulfonylurea agents has proved disappointing, although agents acting on its pore appear more
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