P0248
PNU-37883A
≥98% (HPLC), powder
别名:
N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C21H36ClN3O
化学文摘社编号:
分子量:
381.98
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
color
white
SMILES string
Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5
assay
≥98% (HPLC)
form
powder
solubility
DMSO: ~23 mg/mL, H2O: insoluble
storage temp.
2-8°C
Gene Information
human ... KCNJ8(3764)
Biochem/physiol Actions
Selective inhibitor of Kir6.1/SUR2B channels.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Joy H Tan et al.
The Journal of physiology, 581(Pt 2), 757-765 (2007-03-24)
In rat tail artery, activation of postjunctional alpha(2)-adrenoceptors by noradrenaline (NA) released from sympathetic axons produces a slow depolarization (NAD) of the smooth muscle through a decrease in K(+) conductance. In this study we used intracellular recording to investigate whether
Noriyoshi Teramoto
Cardiovascular drug reviews, 24(1), 25-32 (2006-08-31)
U-37883A (PNU-37883A, guanidine; 4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexyl hydrochloride) was originally developed as a potential diuretic with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells. U-37883A inhibits ATP-sensitive K(+) channels (K(ATP) channels) in vascular smooth muscle
Yi-Ling Chan et al.
Critical care medicine, 40(4), 1261-1268 (2012-03-20)
Excessive opening of the adenosine triphosphate-sensitive potassium channel in vascular smooth muscle is implicated in the vasodilation and vascular hyporeactivity underlying septic shock. Therapeutic channel inhibition using sulfonylurea agents has proved disappointing, although agents acting on its pore appear more
H C Champion et al.
Peptides, 22(9), 1427-1434 (2001-08-22)
Responses to human calcitonin gene-related peptide (hCGRP) and human adrenomedullin (hADM) hAmylin were investigated in isolated mesenteric resistance arteries from the rat. The results of the present investigation show that hCGRP, hAmylin, and hADM induce dose-related vasodilator responses in isolated
Julia Rivo et al.
Anesthesiology, 101(5), 1153-1159 (2004-10-27)
A3 adenosine receptor (AR) activation worsens or protects against renal and cardiac ischemia-reperfusion (IR) injury, respectively. The aims of the current study were to examine in an in vivo model the effect of A3AR activation on IR lung injury and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持