P0872
8-PIP-cAMP
≥98% (HPLC), solid
别名:
8-哌啶腺苷 3′,5′-单磷酸盐 钠盐
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关于此项目
经验公式（希尔记法）:
C15H20N6O6PNa
化学文摘社编号:
分子量:
434.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C15H21N6O6P.Na/c16-12-9-13(18-7-17-12)21(15(19-9)20-4-2-1-3-5-20)14-10(22)11-8(26-14)6-25-28(23,24)27-11;/h7-8,10-11,14,22H,1-6H2,(H,23,24)(H2,16,17,18);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1
SMILES string
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(nc12)N5CCCCC5
InChI key
FNCWZMQKRRKCEF-ZBMQJGODSA-M
assay
≥98% (HPLC)
form
solid
packaging
pkg of 10 μmol
color
white
solubility
H2O: freely soluble
shipped in
dry ice
storage temp.
−70°C
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Simona Lucchi et al.
PloS one, 6(6), e20785-e20785 (2011-06-23)
Cyclic AMP (cAMP) inhibits the proliferation of several tumor cells. We previously reported an antiproliferative effect of PKA I-selective cAMP analogs (8-PIP-cAMP and 8-HA-cAMP) on two human cancer cell lines of different origin. 8-Cl-cAMP, another cAMP analog with known antiproliferative
Elisa Stellaria Grassi et al.
Endocrine, 56(2), 388-398 (2016-07-28)
The main purpose of our work was to evaluate the effects of different cyclic adenosine monophosphate analogs on thyroid cancer-derived cell lines. In particular we studied 8-chloroadenosine-3',5'-cyclic monophosphate, the most powerful cyclic adenosine monophosphate analog, and the protein kinase A
G Gausdal et al.
Cell death & disease, 4, e516-e516 (2013-03-02)
We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect was reproduced in NB4 APL cells, and shown to depend
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