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Merck
CN

P1152

聚(Ala, Glu, Lys, Tyr) 6:2:5:1 氢溴酸盐

greener alternative

Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000

别名:

(L-Ala, L-Glu, L-Lys, L-Tyr)n ·HBr, COP-1

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关于此项目

化学文摘社编号:
28704-27-0
UNSPSC Code:
12352202
NACRES:
NA.26
MDL number:
MFCD00166401

主要文件

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产品名称

聚(Ala, Glu, Lys, Tyr) 6:2:5:1 氢溴酸盐, Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000

SMILES string

N[C@@H](CCCCN)C(=O)O.N[C@@H](Cc1ccc(cc1)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](C)C(=O)O

InChI

1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1

InChI key

YLOCGHYTXIINAI-XKUOMLDTSA-N

form

powder

feed ratio

Ala:Glu:Lys:Tyr (6:2:5:1)

mol wt

20,000-30,000

greener alternative product score

old score: 56
new score: 39
Find out more about DOZN™ Scoring

greener alternative product characteristics

Designing Safer Chemicals
Safer Solvents and Auxiliaries
Reduce Derivatives
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

color

white to off-white

greener alternative category

, Re-engineered

storage temp.

−20°C

Quality Level

200

相关类别

Analysis Note

基于粘度报告的分子量。

Biochem/physiol Actions

聚（Ala，Glu，Lys，Tyr）6:2:5:1氢溴酸盐是一种聚氨基酸，据报道对过敏性脑脊髓炎具有抑制作用。
据报道对实验动物诱发的实验性变态反应性脑脊髓炎有抑制作用。

General description

我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在“设计更安全的化学品”、“更安全的溶剂和助剂”以及“减少衍生物”绿色化学原则方面取得了重大进步。 点击此处查看其 DOZN 记分卡。

Other Notes

有关聚氨基酸的其他技术信息，请访问 聚氨基酸常见问题解答资源。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000331726
0000331726
0000276030
0000276030
SLBH2744V

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M Sela
Applied biochemistry and biotechnology, 83(1-3), 63-70 (2000-05-29)
The conformation of a peptide defines its antigenic specificity. In most cases, a free peptide is in a random form, whereas the same peptide within a protein has a defined conformation. Immunological cross-reactions between the two are rare. Nevertheless, there
R Aharoni et al.
Immunology letters, 58(2), 79-87 (1997-07-01)
Graft-versus-host disease (GVHD), which occurs when donor T-cells recognize multiple minor host histocompatibility antigens as non-self, presents the major limitation to successful allogeneic bone-marrow transplantation. The synthetic random copolymer of the amino acids, L-Glu, L-Lys, L-Ala and L-Tyr, termed GLAT
S D Lytton et al.
Parasite immunology, 15(8), 489-492 (1993-08-01)
The ability of Leishmania mexicana amazonensis to inhibit antigen specific T-cell proliferation against a non-parasite polypeptide antigen, poly(LTyr, LGlu)-poly(DLAla)--poly(LLys), was examined. Infection of mouse peritoneal macrophages by promastigotes blocked the proliferation of the T-cell line, TPB1. This effect was correlated
Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide.
D Teitelbaum et al.
European journal of immunology, 1(4), 242-248 (1971-08-01)
D Teitelbaum et al.
Journal of neural transmission. Supplementum, 49, 85-91 (1997-01-01)
Copolymer 1 (Cop 1), a synthetic copolymer of amino acids, is very effective in suppression of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis (MS). Cop 1 was found incapable of inducing EAE, yet it suppressed EAE in
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