P1225
L-α-Phosphatidyl-D-myo-inositol 3,4-diphosphate, dipalmitoyl
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关于此项目
经验公式（希尔记法）:
C41H81O19P3
化学文摘社编号:
分子量:
970.99
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C41H81O19P3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)55-31-33(57-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-56-63(53,54)60-39-36(44)37(45)40(58-61(47,48)49)41(38(39)46)59-62(50,51)52/h33,36-41,44-46H,3-32H2,1-2H3,(H,53,54)(H2,47,48,49)(H2,50,51,52)/t33-,36-,37-,38+,39+,40+,41+/m1/s1
SMILES string
CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O)OC(=O)CCCCCCCCCCCCCCC
InChI key
HKWJHKSHEWVOSS-OMDJCSNQSA-N
solubility
DMSO: soluble, chloroform: soluble, ethanol: soluble
storage temp.
−20°C
Biochem/physiol Actions
Activates Ca2+-insensitive PKC isotypes δ, ε, and η; activates Akt (a serine-threonine kinase also known as PKBα) by direct interaction with the Akt pleckstrin homology domain.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J Van der Kaay et al.
The Journal of biological chemistry, 274(50), 35963-35968 (1999-12-10)
Signaling by phosphatidylinositol (PI) 3-kinases is mediated by 3-phosphoinositides, which bind to Pleckstrin homology (PH) domains that are present in a wide spectrum of proteins. PH domains can be classified into three groups based on their different lipid binding specificities.
A Toker et al.
The Journal of biological chemistry, 269(51), 32358-32367 (1994-12-23)
The effect of phosphoinositides on the activity of protein kinase C (PKC) isotypes was investigated. PKC alpha, beta I, beta II, gamma, delta, epsilon, eta, and zeta were expressed in baculovirus-infected insect cells and purified by column chromatography. The calcium-activated
T F Franke et al.
Science (New York, N.Y.), 275(5300), 665-668 (1997-01-31)
The regulation of the serine-threonine kinase Akt by lipid products of phosphoinositide 3-kinase (PI 3-kinase) was investigated. Akt activity was found to correlate with the amount of phosphatidylinositol-3,4-bisphosphate (PtdIns-3,4-P2) in vivo, and synthetic PtdIns-3,4-P2 activated Akt both in vitro and
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