一般描述
胃蛋白酶原II是一种主要在胃主细胞中产生的天冬氨酸蛋白酶。它广泛分布于各物种的胃肠道中。胃蛋白酶原II是一种精浆蛋白，还以酶原的形式存在于胃粘膜中。它主要由带底物结合裂隙的β片材组成。该裂隙位于两个裂片之间，由两个催化位点的天冬氨酸（Asp32和Asp215）组成。胃蛋白酶原II基因位于人类染色体6p21.1上。
生化/生理作用
用作胃黏膜状态的一种标志物。
胃蛋白酶原II是一种胃分泌的蛋白水解酶，还具有类似天冬氨酸蛋白酶的特性。胃蛋白酶原II可降解胃中的膳食蛋白质，刺激防御素在精液中的局部抗菌防御。胃蛋白酶原II在处理II型肺泡细胞的分泌途径中至关重要，还用作几种肿瘤和癌症的标记物。
胃蛋白酶原I和II的血清水平间比率可被测定用于鉴定具有胃癌高风险的患者。
外形
液体，20mM Tris-HCl，pH 8.0
储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Kimihiko Yanaoka et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(4), 838-845 (2008-04-10)
Gastric cancer screening using the pepsinogen filter test is receiving wide recognition in Japan owing to convenience, freedom from discomfort or risk, efficiency, and economy. Because the long-term outcomes of cancer development in extensive atrophic gastritis detected by pepsinogen test
Cherie Foster et al.
American journal of physiology. Lung cellular and molecular physiology, 286(2), L382-L387 (2003-10-28)
Pepsinogen C, also known as progastricsin or pepsinogen II, is an aspartic protease expressed primarily in gastric chief cells. Prior microarray studies of an in vitro model of type 2 cell differentiation indicated that pepsinogen C RNA was highly induced
Md Imtaiyaz Hassan et al.
Journal of molecular cell biology, 2(3), 118-127 (2010-03-17)
Progastricsin (PGC) is a major seminal plasma protein having aspartyl proteinases-like activity and showing close sequence similarity to pepsins. PGC is also present as zymogen in gastric mucosa. In this article, we have reviewed all important features of PGC. Furthermore
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持