P1648
5β-Pregnane-3β,11β,17α,21-tetrol-20-one
别名:
3β,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one, 3β-Tetrahydrocortisol
警示用语：
Danger
危险声明
危险分类
Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Franciszek K Główka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 283-289 (2009-12-19)
11Beta-hydroxysteroid dehydrogenase isoform 2 (11beta-HSD2) is responsible for conversion of cortisol (F) to inactive cortisone (E). Disturbance of its activity can cause hypertension. To estimate 11beta-HSD2 activity, besides F and E, their tetrahydro- (THF, THE) as well allo-tetrahydro- (allo-THF, allo-THE)
Andrea Raffaelli et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(2), 278-285 (2005-11-29)
The 11beta-hydroxysteroid dehydrogenase (11beta-HSD) is responsible for the interconversion of both the hormonally inactive cortisone and the active cortisol. This enzyme activity, which has implications in the pathogenesis of numerous diseases, is reflected in the ratio of tetrahydrometabolites of cortisol
E M Freel et al.
Clinical endocrinology, 66(5), 659-665 (2007-03-27)
Corticosteroids can be synthesized in extra-adrenal tissues but the contribution of this to circulating levels in humans is not known. Previous in vitro studies suggest that the 'hybrid' corticosteroid 18-oxocortisol (18-oxoF) is produced from cortisol by aldosterone synthase. We looked
C H Shackleton et al.
Clinical endocrinology, 22(6), 701-712 (1985-06-01)
Four children with 11 beta-hydroxysteroid dehydrogenase deficiency are described. All patients had severe hypertension, hypokalaemia, and low plasma aldosterone and renin activities. Two of the patients were siblings and two were unrelated. The most noticeable biochemical feature of these individuals
A Vermeulen et al.
The Prostate, 14(1), 45-53 (1989-01-01)
The objective of this study was to estimate the minimum in vivo effective oral dose and duration of action of the competitive 5 alpha-reductase inhibitor MK-906, a 4-azasteroid, in humans. Plasma dihydrotesterone (DHT), 5 alpha-androstane-3 alpha,17 beta-diol (AD), and its
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