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Merck
CN

P1999

Sigma-Aldrich

PEAQX 四钠 水合物

≥98% (HPLC)

别名:

NVP-AAM077 四钠 水合物, [ [[(1S)-1-（4-溴苯基）乙基] 氨基]（1,2,3,4-四氢-2,3-二氧代-5-喹喔啉基）甲基] 膦酸 四钠 水合物

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关于此项目

经验公式（希尔记法）:
C17H13BrN3Na4O5P · xH2O
化学文摘社编号:
459836-30-7
分子量:
542.14 (anhydrous basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
329820113
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

water: 10 mg/mL

储存温度

−20°C

SMILES字符串

[Na+].[Na+].[Na+].[Na+].[H]O[H].C[C@H](NC(c1cccc2nc([O-])c([O-])nc12)P([O-])([O-])=O)c3ccc(Br)cc3

InChI

1S/C17H17BrN3O5P.4Na.H2O/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;;1H2/q;4*+1;/p-4/t9-,17?;;;;;/m0...../s1

InChI key

SMGAGBKXHAHCGQ-VSYRWHDMSA-J

应用

PEAQX四钠水合物已被用作大鼠 和小鼠的N-甲基-D-天冬氨酸 (NMDA) 受体 2A (NR2A) 拮抗剂。

生化/生理作用

NMDA 受体拮抗剂。
PEAQX对N-甲基-D-天冬氨酸 (NMDA) 受体2A (NR2A) 的特异性高于对N-甲基-D-天冬氨酸 (NMDA) 受体 2B (NR2B) 的特异性， 并诱导纹状体细胞凋亡。它在激活caspase-3方面的效力不如其立体异构体NVP-AAM007。

特点和优势

该化合物是受体分类及信号转导手册上谷氨酸受体（离子通道家族）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000239892
0000239892
0000119325
0000110516
0000106507

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Yves P Auberson et al.
Bioorganic & medicinal chemistry letters, 12(7), 1099-1102 (2002-03-23)
NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1A/2A over 1A/2B subunit composition was optimized, leading to (1RS,1'S)-PEAQX (9r), which
N C Anastasio et al.
Neuroscience, 163(4), 1181-1191 (2009-08-06)
The mechanism underlying phencyclidine (PCP)-induced apoptosis in perinatal rats and the development of schizophrenia-like behaviors is incompletely understood. We used antagonists for N-methyl-D-aspartate (NMDA) receptor subunit NR2A- and NR2B-containing NMDA receptor to test the hypothesis that the behavioral and apoptotic
Melissa Morales et al.
Psychopharmacology, 231(8), 1797-1807 (2013-09-18)
NMDA antagonists consistently produce social inhibition in adult animals, although effects of these manipulations on social behavior of adolescents are relatively unknown. The aim of this study was to assess potential age differences in the socially inhibitory effects of the
Bihua Feng et al.
British journal of pharmacology, 141(3), 508-516 (2004-01-14)
(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid (PBPD) is a moderate affinity, competitive N-methyl-d-aspartate (NMDA) receptor antagonist with an atypical pattern of selectivity among NMDA receptor 2 subunit (NR2) subunits. We now describe the activity of several derivatives of PBPD tested at both rat brain
Da Song et al.
Neurobiology of learning and memory, 155, 435-445 (2018-09-24)
The CA3 subregion of the hippocampus is important for rapid encoding, storage and retrieval of associative memories. Lesions and pharmacological inhibitions of hippocampal CA3 suggest that it is essential for different memories. However, how CA3 functions in spatial and episodic
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