P201
R(−)-PD 128,908 hydrochloride
>97%, solid
别名:
R(–)-(4aS,10bS)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol
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关于此项目
经验公式（希尔记法）:
C14H19NO3 · HCl
分子量:
285.77
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
InChI
1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1
SMILES string
Cl[H].CCCN1CCO[C@H]2[C@H]1COc3ccc(O)cc23
InChI key
DCFXOTRONMKUJB-QMDUSEKHSA-N
assay
>97%
form
solid
optical activity
[α]21/D −67.2°, c = 0.1 in methanol(lit.)
color
white
solubility
ethanol: >10 mg/mL, DMSO: 18 mg/mL, H2O: 9 mg/mL
Biochem/physiol Actions
Selective D3 dopamine receptor agonist; less active enantiomer of S(+)-PD 128,907 hydrochloride.
Legal Information
Manufactured and sold with the permission of Warner-Lambert Company.
Disclaimer
Light sensitive.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands.
Acri, et al.
European Journal of Pharmacology, 281 (1995)
F Sautel et al.
Neuroreport, 6(2), 329-332 (1995-01-26)
The functional potency of a series of dopamine agonists for increasing mitogenesis, measured by incorporation of [3H]thymidine, was established in transfected cell lines expressing human D2 or D3 receptors. The functional selectivity of agonists markedly differs from their binding selectivity.
H A DeWald et al.
Journal of medicinal chemistry, 33(1), 445-450 (1990-01-01)
The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate affinity for the dopamine (DA) D2 receptor labeled with the DA antagonist ligand [3H]haloperidol and moderate in vivo activity; it attenuated gamma-butyrolactone-stimulated
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
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