P206
Philanthotoxin 343 tris(trifluoroacetate) salt
solid
别名:
PhTX-343, S-N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-4-hydroxy-α-[(1-oxobutyl)amino]-benzenepropanamide tris-trifluoroacetate
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关于此项目
经验公式（希尔记法）:
C23H41N5O3 · 3C2HF3O2
化学文摘社编号:
分子量:
777.67
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
form
solid
color
light yellow-green
solubility
methanol: >8 mg/mL (solutions should be freshly prepared.)
storage temp.
−20°C
SMILES string
OS(=O)(=O)C(F)(F)F.OS(=O)(=O)C(F)(F)F.OS(=O)(=O)C(F)(F)F.CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCNCCCN
InChI
1S/C23H41N5O3.3CHF3O3S/c1-2-7-22(30)28-21(18-19-8-10-20(29)11-9-19)23(31)27-17-6-16-26-14-4-3-13-25-15-5-12-24;3*2-1(3,4)8(5,6)7/h8-11,21,25-26,29H,2-7,12-18,24H2,1H3,(H,27,31)(H,28,30);3*(H,5,6,7)/t21-;;;/m0.../s1
InChI key
QTCLKBFOFGTNMC-YDULTXHLSA-N
Gene Information
rat ... Chrm2(81645), Chrm3(24260)
Application
Philanthotoxin 343 tris(trifluoroacetate) salt has been used as Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) blocker. It has also been used as an effective glutamate receptors blocker in an acute homeostasis paradigm to examine the speed of the Neto-α-mediated homeostatic response in Drosophila.
Biochem/physiol Actions
Blocks NMDA-gated ion channels; synthetic analog of the wasp polyamine amide toxin δ-philanthotoxin.
Philanthotoxin 343 is a synthetic analog of the wasp polyamine amide toxin δ-philanthotoxin. It blocks the activation of ionotropic receptors such as acetylcholine receptor (AChR) or inhibitory glutamate receptors (iGluRs).
Preparation Note
Addition of 1 mL of solvent to vial yields a 1 mM solution.
Legal Information
Sold under license from Columbia University.
Disclaimer
Hygroscopic
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
A light switch controlling Ca2+-permeable AMPA receptors in the retina.
Jeffrey S Diamond
The Journal of physiology, 582(Pt 1), 3-3 (2007-04-28)
D Bowie et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(20), 8175-8185 (1998-10-08)
The mechanisms by which polyamines block AMPA and kainate receptors are not well understood, but it has been generally assumed that they act as open-channel blockers. Consistent with this, voltage-jump relaxation analysis of GluR6 equilibrium responses to domoate could be
Tim J Brier et al.
Molecular pharmacology, 64(4), 954-964 (2003-09-23)
Whole-cell recordings and outside-out patch recordings from TE671 cells were made to investigate antagonism of human muscle nicotinic acetylcholine receptors (nAChR) by the philanthotoxins, PhTX-343 and PhTX-(12). When coapplied with acetylcholine (ACh), PhTX-343 caused activation-dependent, noncompetitive inhibition (IC50 = 17