P216
(±)-PD 128,907 hydrochloride
solid, ≥98% (HPLC)
别名:
trans-(±)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride, PD 125,530
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关于此项目
经验公式（希尔记法）:
C14H19NO3 · HCl
化学文摘社编号:
分子量:
285.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
(±)-PD 128,907 hydrochloride, solid, ≥98% (HPLC)
InChI
1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1
SMILES string
Cl.CCCN1CCO[C@H]2[C@H]1COc3ccc(O)cc23
InChI key
DCFXOTRONMKUJB-QMDUSEKHSA-N
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
white
solubility
H2O: >5 mg/mL
Gene Information
human ... DRD3(1814)
Biochem/physiol Actions
Selective D3 dopamine receptor agonist.
Disclaimer
Light sensitive.
Legal Information
Manufactured and sold with the permission of Warner-Lambert Company.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
A Gobert et al.
Journal of neurochemistry, 66(5), 2209-2212 (1996-05-01)
In freely moving rats, the novel, selective dopamine (DA) D3 receptor agonist PD 128,907 dose-dependently [effective dose (ED25) = 0.07 mg/kg, s.c.] reduced dialysate levels of DA in the frontal cortex, a structure innervated by the ventral tegmental area (VTA).
T A Pugsley et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1355-1366 (1995-12-01)
The present study determined the biochemical and pharmacological effects of PD 128907 [R-(+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H- [1]benzopyrano[4,3-b]-1,4-oxazin-9-ol], a dopamine (DA) receptor agonist that shows a preference for the human D3 receptor. In transfected Chinese hamster ovary cells (CHO K1), PD 128907 displaced [3H]spiperone
H A DeWald et al.
Journal of medicinal chemistry, 33(1), 445-450 (1990-01-01)
The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate affinity for the dopamine (DA) D2 receptor labeled with the DA antagonist ligand [3H]haloperidol and moderate in vivo activity; it attenuated gamma-butyrolactone-stimulated
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