P265
Penitrem A
solid
别名:
(5H,7H)-triol, 12-Chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cylcobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d, Tremortin A
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关于此项目
UNSPSC Code:
41116107
form
solid
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white
solubility
methanol: 10 mg/mL
format
neat
storage temp.
−20°C
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Selective blocker of high conductance Ca2+-activated (Maxi-K) potassium channels.
法规信息
新产品
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J B Cavanagh et al.
Veterinary pathology, 35(1), 53-63 (1998-04-17)
Within 10 minutes of intraperitoneal injection of penitrem A (3 mg/kg), rats develop severe generalized tremors and ataxia that persist for up to 48 hours. These are accompanied by a three- to fourfold increase in cerebellar cortical blood flow. Mitochondrial
P Breton et al.
Toxicon : official journal of the International Society on Toxinology, 36(4), 645-655 (1998-06-27)
The neurotoxicity of Penitrem A (PA) in rats was assessed against neurophysiological, behavioral and histopathological parameters. Animals were acutely given intracerebroventricular (22-45 mg) or intraperitoneal injections (0.5-1.5 mg/kg) of PA. A typical trembling syndrome associated with PA was always noted.