P2803
N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide
别名:
SC-9
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关于此项目
经验公式（希尔记法）:
C22H24ClNO2S
化学文摘社编号:
分子量:
401.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
solid
InChI
1S/C22H24ClNO2S/c23-21-15-8-14-20-19(21)13-9-16-22(20)27(25,26)24-17-7-2-1-4-10-18-11-5-3-6-12-18/h3,5-6,8-9,11-16,24H,1-2,4,7,10,17H2
SMILES string
Clc1cccc2c(cccc12)S(=O)(=O)NCCCCCCc3ccccc3
InChI key
YUXMTDYHFPRPLG-UHFFFAOYSA-N
form
solid
storage temp.
−20°C
Biochem/physiol Actions
Activates protein kinase C in a Ca2+-dependent manner
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A D Blest et al.
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 170(2), 189-199 (1992-02-01)
1. Retinae of crabs, Leptograpsus variegatus, held on a 12:12 h light-dark cycle were prepared for culture in vitro shortly before light-off. After an hour in darkness to permit the assembly of "night" rhabdoms, retinae were exposed to various combinations
K Ashizawa et al.
Journal of reproduction and fertility, 101(3), 511-517 (1994-08-01)
The presence and possible role of protein kinase C in the regulation of fowl sperm functions were investigated. Immunoblot analysis of sperm extract using antibody to protein kinase C revealed a crossreacting protein of approximately 80 kDa. As the concentration
R Yang et al.
Calcified tissue international, 61(1), 68-73 (1997-07-01)
Protein kinase C (PKC) plays an important role in the differentiation of cells, however, little is known about its relationship to bone metabolism. We have previously demonstrated that staurosporine concentration dependently transformed the cultured rat osteoblasts into stellate cells. In
P H Watson et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 7(6), 667-674 (1992-06-01)
The response of the parathyroid gland to low Ca2+ may be mediated in part by protein kinase C (PKC). We assessed the effect of two PKC activators, SC-9 and SC-10, and one PKC inhibitor, H-7, on Ca(2+)-regulated PTH release and
C E Somers et al.
The Journal of biological chemistry, 268(30), 22277-22280 (1993-10-25)
Fibroblasts have cell surface sites that mediate the assembly of fibronectin (Fn) into the extracellular matrix. Treatment of fibroblasts with kinase inhibitors (ML-7, H7, HA1004, calphostin C, and staurosporine) resulted in the rapid decrease in the binding of 125I-labeled plasma
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