Monoclonal Anti-p59^fyn antibody produced in mouse

The signalling in T cells is mediated by receptor and non-receptor protein tyrosine kinases (PTK). Two non-receptors PTK that belong to Src family, Fyn and Lck are vital for T-cell development and function. Both Fyn and Lck have unique domains that undergo post-translational modifications such as palmitoylation, myristoylation and acetylation od specific cysteine residues that are critical for T cell signalling. Fyn is generally associated with intracellular structures such as mitotic spindles. Both Fyn and Lck are closely associated in T cell differentiation, expansion and mediating TCR-mediated survival signals in naïve T cells. Both the kinases have partially overlapping functions and have the ability to compensate if either kinase is deficient.
Monoclonal Anti- p59^fyn specifically recognizes human, mouse and rat Fyn protein (~59 kDa).

amino acids 1-206 from recombinant murine p59^fyn

Monoclonal Anti- p59^fyn may be used for detection by immunohistochemistry of formalin-fixed, paraffin-embedded human lymphoid tissue sections at a working concentration of 1-5 μg/mL. The recommended concentration for immunoprecipitation is 2μg/mg of lysate. The antibody is also suitable for immunoblotting and ELISA.

Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.

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