Anti-PDK1 antibody produced in rabbit

The 3-phosphoinositide-dependent protein kinase-1 (PDK1, PKB kinase), is a master regulator of AGC kinases. It mediates cellular effects by activating major pathways involving PKB/Akt , S6K, RSK, SGK and the PKC isoforms. PDK1 is ubiquitously present in cells and is constitutively active. PDK1 is a critical activator of PKB/Akt as it mediates phosphorylation at Thr³⁰⁸ in the catalytic domain, thus plays a significant role on oncogenic signalling by PI3K, cell growth, survival, proliferation and migration. By regulating AGC kinases PDK1 is actively involved in the regulation of protein translation and metabolism, and serum and gluco-corticoid induced signalling.
Anti-PDK1 recognizes human PDK1 (60 kDa).

synthetic peptide corresponding to the C-terminus of human PDK1 (amino acids 538-556).

Anti-PDK-1 may be used for detection by immunoblotting at a working dilution of 1:1000. The antibody is suitable for protein microarray.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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