P4368
粉蝶霉素A 来源于微生物源
>95% (HPLC), DMSO solution
别名:
2,6,9,11-邻苯二酚-4-醇,13-(4-羟基-5,6-二甲氧基-3-甲基-2-吡啶基)-3,5,7,11-四甲基-(all-E)-(4R,5R), 4-吡啶醇,2-(10-羟基-3,7,9,11-四甲基-2,5,7,11-三苯邻二甲苯基)-5,6-二甲氧基- [R-[R*,R*-(all-E)]]-3-甲基-, SN 198E, Shaoguamycin B, 粉蝶霉素A1
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关于此项目
经验公式（希尔记法）:
C25H37NO4
化学文摘社编号:
分子量:
415.57
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
>95% (HPLC)
form
DMSO solution
shipped in
wet ice
storage temp.
2-8°C
SMILES string
COc1nc(C\C=C(/C)C\C=C\C(C)=C\[C@@H](C)[C@@H](O)\C(C)=C\C)c(C)c(O)c1OC
InChI
1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-10,12-13,15,19,22,27H,11,14H2,1-8H3,(H,26,28)/b12-10+,16-13+,17-15+,18-9+/t19-,22+/m1/s1
InChI key
BBLGCDSLCDDALX-LKGBESRRSA-N
Biochem/physiol Actions
杀粉蝶菌素A（PA），是 茂源链霉菌 的杀虫代谢物，其是潜在的群体感应抑制剂（QSI），可以破坏胡萝卜欧文氏菌 亚种 atroseptica (Eca)的毒力基因的表达。因此，它可用作马铃薯块茎上软腐病的防治剂。
杀粉蝶菌素A是线粒体和细菌I型NADH-泛醌氧化还原酶（复合物I）的有效抑制剂。它被认为能与酶的泛醌结合位点结合。杀粉蝶菌素A使复合物I失活可完全阻止NADH内源性泛醌还原酶反应中NADH诱导的质子移位。
线粒体和细菌I型NADH-泛醌氧化还原酶（复合体I）的有效抑制剂。
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
185.0 °F - closed cup
flash_point_c
85 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Structure of piericidin A
Takahashi N, et al.
Journal of the American Chemical Society, 87(9), 2066-2068 (1965)
J Fang et al.
European journal of biochemistry, 268(10), 3075-3082 (2001-05-19)
Additional characterization of complex I, rotenone-sensitive NADH:ubiquinone oxidoreductase, in the mitochondria of Trypanosoma brucei brucei has been obtained. Both proline:cytochrome c reductase and NADH:ubiquinone oxidoreductase of procyclic T. brucei were inhibited by the specific inhibitors of complex I rotenone, piericidin
J G Okun et al.
The Journal of biological chemistry, 274(5), 2625-2630 (1999-01-23)
We have developed two independent methods to measure equilibrium binding of inhibitors to membrane-bound and partially purified NADH:ubiquinone oxidoreductase (complex I) to characterize the binding sites for the great variety of hydrophobic compounds acting on this large and complicated enzyme.
Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species.
Romana Fato et al.
Biochimica et biophysica acta, 1787(5), 384-392 (2008-12-09)
We have investigated the production of reactive oxygen species (ROS) by Complex I in isolated open bovine heart submitochondrial membrane fragments during forward electron transfer in presence of NADH, by means of the probe 2',7'-Dichlorodihydrofluorescein diacetate. ROS production by Complex
Nobuhiro Ikezawa et al.
Bioscience, biotechnology, and biochemistry, 66(9), 1925-1929 (2002-10-29)
The effects of several respiration inhibitors on photosystem II (PS II) were investigated. Among the agents tested, piericidin A and thenoyltrifluoroacetone (TTFA) inhibited the photosynthetic electron transport of spinach as measured from chlorophyll (Chl) fluorescence parameters (Fm'-F)/Fm' and Fv/Fm. Using
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