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P4374

酞菁四磺酸盐 水合物

solid

别名:

29H,29H,31H-酞菁-C,C,C,C-四磺酸, PcTS, 四磺酞菁, 酞菁四磺酸

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关于此项目

经验公式（希尔记法）:
C32H18N8O12S4 · xH2O
化学文摘社编号:
1173097-70-5
分子量:
834.79 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24724578
MDL number:
MFCD08276972
Form:
solid
Quality level:
100
Storage condition:
protect from light
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form

solid

Quality Level

100

storage condition

protect from light

color

dark blue

storage temp.

2-8°C

SMILES string

[H]O[H].OS(=O)(=O)c1ccc2c3nc(nc4[nH]c(nc5nc(nc6[nH]c(n3)c7cc(ccc67)S(O)(=O)=O)c8cc(ccc58)S(O)(=O)=O)c9cc(ccc49)S(O)(=O)=O)c2c1

InChI

1S/C32H18N8O12S4.H2O/c41-53(42,43)13-1-5-17-21(9-13)29-33-25(17)37-30-22-10-14(54(44,45)46)2-6-18(22)27(34-30)39-32-24-12-16(56(50,51)52)4-8-20(24)28(36-32)40-31-23-11-15(55(47,48)49)3-7-19(23)26(35-31)38-29;/h1-12H,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H2,33,34,35,36,37,38,39,40);1H2

InChI key

QNPPZKALMXYKPI-UHFFFAOYSA-N

Application

酞菁四磺酸盐水合物已被用作 tau 蛋白聚集抑制剂 (TAI) ，用于研究其对神经母细胞瘤细胞中 Tau 分泌的影响。它还可用作阴离子酞菁，研究其对端粒 G-四链体稳定性的影响。

Biochem/physiol Actions

蛋白质聚集的抑制剂，包括α-突触核蛋白，以及耐受蛋白酶的朊病毒蛋白的形成。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
080M4719
125K4710

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Chang-yue Chen et al.
Journal of the American Chemical Society, 133(38), 15036-15044 (2011-08-19)
Inhibition of telomerase activity through stabilizing telomere G-quadruplex with small chemical ligands is emerging as a novel strategy for cancer therapy. For the large number of ligands that have been reported to inhibit telomerase activity, it is difficult to validate
Takao Ohtomo et al.
Journal of analytical methods in chemistry, 2012, 520248-520248 (2012-05-09)
The chemiluminescence (CL) signal immediately appeared when a hydrogen peroxide solution was injected into an iron-phthalocyanine tetrasulfonic acid (Fe-PTS) aqueous solution. Moreover, the CL intensity of Fe-PTS decreased by adding l-tyrosine. Based on these results, the determination of trace amounts
Maria Merezhko et al.
Cell reports, 25(8), 2027-2035 (2018-11-22)
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that appear to spread throughout the brain via a cell-to-cell transmission process that includes secretion and uptake of pathological Tau, followed by templated misfolding of normal Tau in recipient cells.
Ciaran K McLoughlin et al.
Sensors (Basel, Switzerland), 20(18) (2020-09-16)
Fluorescein, and derivatives of fluorescein, are often used as fluorescent probes and sensors. In systems where pH is a variable, protonation/deprotonation of the molecule can influence the pertinent photophysics. Fluorination of the xanthene moiety can alter the molecule's pKa such
Luis Fonseca-Ornelas et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(53), 13010-13014 (2017-08-02)
Accumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar species remain unclear. Here, we show that αSyn can form in solution α-helical oligomers
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全球贸易项目编号

货号GTIN
P4374-25MG04061832981956

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