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Merck
CN

P4374

Sigma-Aldrich

酞菁四磺酸盐 水合物

solid

别名:

29H,29H,31H-酞菁-C,C,C,C-四磺酸, PcTS, 四磺酞菁, 酞菁四磺酸

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关于此项目

经验公式(希尔记法):
C32H18N8O12S4 · xH2O
化学文摘社编号:
分子量:
834.79 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
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表单

solid

质量水平

储存条件

protect from light

颜色

dark blue

储存温度

2-8°C

SMILES字符串

[H]O[H].OS(=O)(=O)c1ccc2c3nc(nc4[nH]c(nc5nc(nc6[nH]c(n3)c7cc(ccc67)S(O)(=O)=O)c8cc(ccc58)S(O)(=O)=O)c9cc(ccc49)S(O)(=O)=O)c2c1

InChI

1S/C32H18N8O12S4.H2O/c41-53(42,43)13-1-5-17-21(9-13)29-33-25(17)37-30-22-10-14(54(44,45)46)2-6-18(22)27(34-30)39-32-24-12-16(56(50,51)52)4-8-20(24)28(36-32)40-31-23-11-15(55(47,48)49)3-7-19(23)26(35-31)38-29;/h1-12H,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H2,33,34,35,36,37,38,39,40);1H2

InChI key

QNPPZKALMXYKPI-UHFFFAOYSA-N

应用

酞菁四磺酸盐水合物已被用作 tau 蛋白聚集抑制剂 (TAI) ,用于研究其对神经母细胞瘤细胞中 Tau 分泌的影响。它还可用作阴离子酞菁,研究其对端粒 G-四链体稳定性的影响。

生化/生理作用

蛋白质聚集的抑制剂,包括α-突触核蛋白,以及耐受蛋白酶的朊病毒蛋白的形成。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Eui-Nam Lee et al.
Biochemistry, 43(12), 3704-3715 (2004-03-24)
Alpha-synuclein is a pathological component of Parkinson's disease by constituting the filamentous component of Lewy bodies. Phthalocyanine (Pc) effects on the amyloidosis of alpha-synuclein have been examined. The copper complex of phthalocyanine tetrasulfonate (PcTS-Cu(2+)) caused the self-oligomerization of alpha-synuclein while
Suzette A Priola et al.
The Journal of infectious diseases, 188(5), 699-705 (2003-08-23)
The transmissible spongiform encephalopathy (TSE) diseases are rare, neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans. There are no effective treatments available for clinical use in humans. We now demonstrate that, in 2
Chang-yue Chen et al.
Journal of the American Chemical Society, 133(38), 15036-15044 (2011-08-19)
Inhibition of telomerase activity through stabilizing telomere G-quadruplex with small chemical ligands is emerging as a novel strategy for cancer therapy. For the large number of ligands that have been reported to inhibit telomerase activity, it is difficult to validate
Ciaran K McLoughlin et al.
Sensors (Basel, Switzerland), 20(18) (2020-09-16)
Fluorescein, and derivatives of fluorescein, are often used as fluorescent probes and sensors. In systems where pH is a variable, protonation/deprotonation of the molecule can influence the pertinent photophysics. Fluorination of the xanthene moiety can alter the molecule's pKa such
Ariel A Valiente-Gabioud et al.
Biophysical journal, 114(5), 1036-1045 (2018-03-15)
The inherent tendency of proteins to convert from their native states into amyloid aggregates is associated with a range of human disorders, including Alzheimer's and Parkinson's diseases. In that sense, the use of small molecules as probes for the structural

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