P4509
棕榈酰-DL-肉碱氯化物
synthetic (organic), ≥98% (TLC), PKC inhibitor, powder
别名:
DL-Hexadecanoylcarnitine, Hexadecanoyl-DL-carnitine, NSC 628323, DL-Palmitoylcarnitine
产品名称
棕榈酰-DL-肉碱氯化物, powder
生物来源
synthetic (organic)
质量水平
方案
≥98% (TLC)
表单
powder
颜色
white
溶解性
H2O: 25 mg/mL (with heat or sonication)
储存温度
−20°C
SMILES字符串
Cl.CCCCCCCCCCCCCCCC(=O)OC(CC(O)=O)C[N](C)(C)C
InChI
1S/C23H46NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3,(H,25,26);1H
InChI key
LGVBWSFTXDIBPB-UHFFFAOYSA-N
应用
使用前列腺癌的体外模型，已使用棕榈酰-DL-肉碱氯化物研究其对炎性细胞因子和钙（Ca2+）内流的影响。
生化/生理作用
已知棕榈酰-DL-肉碱氯化物可抑制铜绿假单胞菌和大肠埃希菌介导的生物膜形成。它是一种磷酸激酶C抑制剂。
长链酰基肉碱和线粒体脂肪酸氧化的众所周知的中间体。改变心脏中高能磷酸盐和游离脂肪酸的心肌水平。增加培养物中红细胞集落的形成。减少红细胞和心肌细胞的表面负电荷。据报道，通过抑制内皮细胞内钙信号转导，影响电流并抑制乙酰胆碱和物质P诱导的内皮依赖性舒张，呈剂量依赖性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Journal of Chemical and Pharmaceutical Sciences
, 76(14), 29-29 (2012)
Accumulation of Palmitoylcarnitine and Its Effect on Pro-Inflammatory Pathways and Calcium Influx in Prostate Cancer
Al-Bakheit A, et al.
Prostate, 76(14), 1326-1337 (2016)
Signal transduction of the prophenoloxidase-activating system of prawn haemocytes triggered by CpG oligodeoxynucleotides
Chuo CP, et al.
Fish & Shellfish Immunology, 18(2), 149-162 (2005)
N Inoue et al.
Cardiovascular research, 28(1), 129-134 (1994-01-01)
Palmitoyl-L-carnitine, which accumulates in ischaemic myocardium, may influence the function of vascular endothelium in the ischaemic area. The aim of the study was therefore to examine the effect of palmitoyl-L-carnitine on endothelium dependent relaxations of rabbit thoracic aortas and its
Chih Hung Lo et al.
Protein science : a publication of the Protein Society, 29(6), 1401-1415 (2020-01-22)
Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that plays a key role in the regulation of the inflammatory pathway. While inhibition of TNFR1 has been the focus of many studies for the treatment of autoimmune diseases such
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