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P4509

棕榈酰-DL-肉碱氯化物

Name: 棕榈酰-<SC>DL</SC>-肉碱氯化物
Brand: SIGMA

synthetic (organic), ≥98% (TLC), PKC inhibitor, powder

别名:

DL-Hexadecanoylcarnitine, Hexadecanoyl-DL-carnitine, NSC 628323, DL-Palmitoylcarnitine

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关于此项目

线性分子式:

C₂₃H₄₆NO₄ · Cl

化学文摘社编号:

6865-14-1

分子量:

436.07

UNSPSC Code:

12352200

PubChem Substance ID:

24278634

NACRES:

NA.77

MDL number:

MFCD00063481

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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产品名称

棕榈酰-DL-肉碱氯化物, powder

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

color

white

solubility

H₂O: 25 mg/mL (with heat or sonication)

storage temp.

−20°C

SMILES string

Cl.CCCCCCCCCCCCCCCC(=O)OC(CC(O)=O)C[N](C)(C)C

InChI

1S/C23H46NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3,(H,25,26);1H

InChI key

LGVBWSFTXDIBPB-UHFFFAOYSA-N

Application

使用前列腺癌的体外模型，已使用棕榈酰-DL-肉碱氯化物研究其对炎性细胞因子和钙（Ca²⁺）内流的影响。

Biochem/physiol Actions

已知棕榈酰-DL-肉碱氯化物可抑制铜绿假单胞菌和大肠埃希菌介导的生物膜形成。它是一种磷酸激酶C抑制剂。

长链酰基肉碱和线粒体脂肪酸氧化的众所周知的中间体。改变心脏中高能磷酸盐和游离脂肪酸的心肌水平。增加培养物中红细胞集落的形成。减少红细胞和心肌细胞的表面负电荷。据报道，通过抑制内皮细胞内钙信号转导，影响电流并抑制乙酰胆碱和物质P诱导的内皮依赖性舒张，呈剂量依赖性。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Palmitoyl-L-carnitine modifies the function of vascular endothelium.

N Inoue et al.

Cardiovascular research, 28(1), 129-134 (1994-01-01)

Palmitoyl-L-carnitine, which accumulates in ischaemic myocardium, may influence the function of vascular endothelium in the ischaemic area. The aim of the study was therefore to examine the effect of palmitoyl-L-carnitine on endothelium dependent relaxations of rabbit thoracic aortas and its

Effect of membrane incorporation of 1-palmitoylcarnitine on surface charge of human erythrocytes.

C Gruver et al.

Journal of molecular and cellular cardiology, 25(10), 1275-1284 (1993-10-01)

1-Palmitoylcarnitine (1-PC) reduced the electrophoretic mobility of human erythrocytes bathed in low ionic strength solution. Unlike divalent cations which appear to reduce electrophoretic mobility by screening surface negative charge, cationic 1-PC does so by being incorporated into the plasma membrane.

Conformational states of TNFR1 as a molecular switch for receptor function.

Chih Hung Lo et al.

Protein science : a publication of the Protein Society, 29(6), 1401-1415 (2020-01-22)

Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that plays a key role in the regulation of the inflammatory pathway. While inhibition of TNFR1 has been the focus of many studies for the treatment of autoimmune diseases such

Journal of Chemical and Pharmaceutical Sciences , 76(14), 29-29 (2012)

Accumulation of Palmitoylcarnitine and Its Effect on Pro-Inflammatory Pathways and Calcium Influx in Prostate Cancer

Al-Bakheit A, et al.

Prostate, 76(14), 1326-1337 (2016)

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全球贸易项目编号

货号	GTIN
P4509-100MG	04061832434131
P4509-1G	04061826132159

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