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P4509

棕榈酰-DL-肉碱氯化物

Name: 棕榈酰-<SC>DL</SC>-肉碱氯化物
Brand: SIGMA

synthetic (organic), ≥98% (TLC), PKC inhibitor, powder

别名:

DL-Hexadecanoylcarnitine, Hexadecanoyl-DL-carnitine, NSC 628323, DL-Palmitoylcarnitine

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关于此项目

线性分子式:

C₂₃H₄₆NO₄ · Cl

化学文摘社编号:

6865-14-1

分子量:

436.07

UNSPSC Code:

12352200

PubChem Substance ID:

24278634

NACRES:

NA.77

MDL number:

MFCD00063481

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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属性

产品名称

棕榈酰-DL-肉碱氯化物, powder

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

color

white

solubility

H₂O: 25 mg/mL (with heat or sonication)

storage temp.

−20°C

SMILES string

Cl.CCCCCCCCCCCCCCCC(=O)OC(CC(O)=O)C[N](C)(C)C

InChI

1S/C23H46NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3,(H,25,26);1H

InChI key

LGVBWSFTXDIBPB-UHFFFAOYSA-N

说明

Application

使用前列腺癌的体外模型，已使用棕榈酰-DL-肉碱氯化物研究其对炎性细胞因子和钙（Ca²⁺）内流的影响。

Biochem/physiol Actions

已知棕榈酰-DL-肉碱氯化物可抑制铜绿假单胞菌和大肠埃希菌介导的生物膜形成。它是一种磷酸激酶C抑制剂。

长链酰基肉碱和线粒体脂肪酸氧化的众所周知的中间体。改变心脏中高能磷酸盐和游离脂肪酸的心肌水平。增加培养物中红细胞集落的形成。减少红细胞和心肌细胞的表面负电荷。据报道，通过抑制内皮细胞内钙信号转导，影响电流并抑制乙酰胆碱和物质P诱导的内皮依赖性舒张，呈剂量依赖性。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Palmitoyl-L-carnitine modifies the function of vascular endothelium.

N Inoue et al.

Cardiovascular research, 28(1), 129-134 (1994-01-01)

Palmitoyl-L-carnitine, which accumulates in ischaemic myocardium, may influence the function of vascular endothelium in the ischaemic area. The aim of the study was therefore to examine the effect of palmitoyl-L-carnitine on endothelium dependent relaxations of rabbit thoracic aortas and its

Effect of membrane incorporation of 1-palmitoylcarnitine on surface charge of human erythrocytes.

C Gruver et al.

Journal of molecular and cellular cardiology, 25(10), 1275-1284 (1993-10-01)

1-Palmitoylcarnitine (1-PC) reduced the electrophoretic mobility of human erythrocytes bathed in low ionic strength solution. Unlike divalent cations which appear to reduce electrophoretic mobility by screening surface negative charge, cationic 1-PC does so by being incorporated into the plasma membrane.

Conformational states of TNFR1 as a molecular switch for receptor function.

Chih Hung Lo et al.

Protein science : a publication of the Protein Society, 29(6), 1401-1415 (2020-01-22)

Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that plays a key role in the regulation of the inflammatory pathway. While inhibition of TNFR1 has been the focus of many studies for the treatment of autoimmune diseases such

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